Ultramicronized N-Palmitoylethanolamine Regulates Mast Cell-Astrocyte Crosstalk: A New Potential Mechanism Underlying the Inhibition of Morphine Tolerance

Persistent pain can be managed with opioids, but their use is limited by the onset of tolerance. Ultramicronized N-palmitoylethanolamine (PEA) in vivo delays morphine tolerance with mechanisms that are still unclear. Since glial cells are involved in opioid tolerance and mast cells (MCs) are pivotal...

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Detalles Bibliográficos
Autores principales: Toti, Alessandra, Micheli, Laura, Lucarini, Elena, Ferrara, Valentina, Ciampi, Clara, Margiotta, Francesco, Failli, Paola, Gomiero, Chiara, Pallecchi, Marco, Bartolucci, Gianluca, Ghelardini, Carla, Di Cesare Mannelli, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953591/
https://www.ncbi.nlm.nih.gov/pubmed/36830602
http://dx.doi.org/10.3390/biom13020233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953591/
https://www.ncbi.nlm.nih.gov/pubmed/36830602
http://dx.doi.org/10.3390/biom13020233

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