Cargando…
Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical rese...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953604/ https://www.ncbi.nlm.nih.gov/pubmed/36830957 http://dx.doi.org/10.3390/biomedicines11020422 |
_version_ | 1784893918880464896 |
---|---|
author | Camino, Tamara Lago-Baameiro, Nerea Pardo, María |
author_facet | Camino, Tamara Lago-Baameiro, Nerea Pardo, María |
author_sort | Camino, Tamara |
collection | PubMed |
description | Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical research not only as a non-classic cell secretion mechanism, but as a rich source of biomarkers and as useful drug-delivery vehicles. Although the research about the role of EVs on metabolism and its deregulation on obesity and associated pathologies lagged slightly behind other diseases, the knowledge about their function under normal and pathological homeostasis is rapidly increasing. In this review, we are focusing on the current research regarding adipose tissue shed extracellular vesicles including their characterization, size profile, and molecular cargo content comprising miRNAs and membrane and intra-vesicular proteins. Finally, we will focus on the functional aspects attributed to vesicles secreted not only by adipocytes, but also by other cells comprising adipose tissue, describing the evidence to date on the deleterious effects of extracellular vesicles released by obese adipose tissue both locally and at the distant level by interacting with other peripheral organs and even at the central level. |
format | Online Article Text |
id | pubmed-9953604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99536042023-02-25 Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity Camino, Tamara Lago-Baameiro, Nerea Pardo, María Biomedicines Review Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical research not only as a non-classic cell secretion mechanism, but as a rich source of biomarkers and as useful drug-delivery vehicles. Although the research about the role of EVs on metabolism and its deregulation on obesity and associated pathologies lagged slightly behind other diseases, the knowledge about their function under normal and pathological homeostasis is rapidly increasing. In this review, we are focusing on the current research regarding adipose tissue shed extracellular vesicles including their characterization, size profile, and molecular cargo content comprising miRNAs and membrane and intra-vesicular proteins. Finally, we will focus on the functional aspects attributed to vesicles secreted not only by adipocytes, but also by other cells comprising adipose tissue, describing the evidence to date on the deleterious effects of extracellular vesicles released by obese adipose tissue both locally and at the distant level by interacting with other peripheral organs and even at the central level. MDPI 2023-02-01 /pmc/articles/PMC9953604/ /pubmed/36830957 http://dx.doi.org/10.3390/biomedicines11020422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Camino, Tamara Lago-Baameiro, Nerea Pardo, María Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title | Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title_full | Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title_fullStr | Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title_full_unstemmed | Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title_short | Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity |
title_sort | extracellular vesicles as carriers of adipokines and their role in obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953604/ https://www.ncbi.nlm.nih.gov/pubmed/36830957 http://dx.doi.org/10.3390/biomedicines11020422 |
work_keys_str_mv | AT caminotamara extracellularvesiclesascarriersofadipokinesandtheirroleinobesity AT lagobaameironerea extracellularvesiclesascarriersofadipokinesandtheirroleinobesity AT pardomaria extracellularvesiclesascarriersofadipokinesandtheirroleinobesity |