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Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity

Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical rese...

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Detalles Bibliográficos
Autores principales: Camino, Tamara, Lago-Baameiro, Nerea, Pardo, María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953604/
https://www.ncbi.nlm.nih.gov/pubmed/36830957
http://dx.doi.org/10.3390/biomedicines11020422
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author Camino, Tamara
Lago-Baameiro, Nerea
Pardo, María
author_facet Camino, Tamara
Lago-Baameiro, Nerea
Pardo, María
author_sort Camino, Tamara
collection PubMed
description Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical research not only as a non-classic cell secretion mechanism, but as a rich source of biomarkers and as useful drug-delivery vehicles. Although the research about the role of EVs on metabolism and its deregulation on obesity and associated pathologies lagged slightly behind other diseases, the knowledge about their function under normal and pathological homeostasis is rapidly increasing. In this review, we are focusing on the current research regarding adipose tissue shed extracellular vesicles including their characterization, size profile, and molecular cargo content comprising miRNAs and membrane and intra-vesicular proteins. Finally, we will focus on the functional aspects attributed to vesicles secreted not only by adipocytes, but also by other cells comprising adipose tissue, describing the evidence to date on the deleterious effects of extracellular vesicles released by obese adipose tissue both locally and at the distant level by interacting with other peripheral organs and even at the central level.
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spelling pubmed-99536042023-02-25 Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity Camino, Tamara Lago-Baameiro, Nerea Pardo, María Biomedicines Review Extracellular vesicles (EVs) have lately arisen as new metabolic players in energy homeostasis participating in intercellular communication at the local and distant levels. These nanosized lipid bilayer spheres, carrying bioactive molecular cargo, have somehow changed the paradigm of biomedical research not only as a non-classic cell secretion mechanism, but as a rich source of biomarkers and as useful drug-delivery vehicles. Although the research about the role of EVs on metabolism and its deregulation on obesity and associated pathologies lagged slightly behind other diseases, the knowledge about their function under normal and pathological homeostasis is rapidly increasing. In this review, we are focusing on the current research regarding adipose tissue shed extracellular vesicles including their characterization, size profile, and molecular cargo content comprising miRNAs and membrane and intra-vesicular proteins. Finally, we will focus on the functional aspects attributed to vesicles secreted not only by adipocytes, but also by other cells comprising adipose tissue, describing the evidence to date on the deleterious effects of extracellular vesicles released by obese adipose tissue both locally and at the distant level by interacting with other peripheral organs and even at the central level. MDPI 2023-02-01 /pmc/articles/PMC9953604/ /pubmed/36830957 http://dx.doi.org/10.3390/biomedicines11020422 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Camino, Tamara
Lago-Baameiro, Nerea
Pardo, María
Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title_full Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title_fullStr Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title_full_unstemmed Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title_short Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
title_sort extracellular vesicles as carriers of adipokines and their role in obesity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953604/
https://www.ncbi.nlm.nih.gov/pubmed/36830957
http://dx.doi.org/10.3390/biomedicines11020422
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