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Development of a TGFβ—IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy
Therapy employing T cells modified with chimeric antigen receptors (CARs) is effective in hematological malignancies but not yet in solid cancers. CAR T cell activity in solid tumors is limited by immunosuppressive factors, including transforming growth factor β (TGFβ). Here, we describe the develop...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953633/ https://www.ncbi.nlm.nih.gov/pubmed/36830995 http://dx.doi.org/10.3390/biomedicines11020459 |