Cargando…

Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome

(1) Background: Abnormally increased arterial and aortic stiffness (AS and AoS), which are often associated with diastolic dysfunction (DD), represent common alterations in COVID-19. In this study, we aimed to assess, by transthoracic echocardiography (TTE) and pulse-wave velocity (PWV), the frequen...

Descripción completa

Detalles Bibliográficos
Autores principales: Tudoran, Cristina, Bende, Felix, Bende, Renata, Giurgi-Oncu, Catalina, Dumache, Raluca, Tudoran, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953636/
https://www.ncbi.nlm.nih.gov/pubmed/36831027
http://dx.doi.org/10.3390/biomedicines11020492
_version_ 1784893927081377792
author Tudoran, Cristina
Bende, Felix
Bende, Renata
Giurgi-Oncu, Catalina
Dumache, Raluca
Tudoran, Mariana
author_facet Tudoran, Cristina
Bende, Felix
Bende, Renata
Giurgi-Oncu, Catalina
Dumache, Raluca
Tudoran, Mariana
author_sort Tudoran, Cristina
collection PubMed
description (1) Background: Abnormally increased arterial and aortic stiffness (AS and AoS), which are often associated with diastolic dysfunction (DD), represent common alterations in COVID-19. In this study, we aimed to assess, by transthoracic echocardiography (TTE) and pulse-wave velocity (PWV), the frequency of these dysfunctions in patients with post-acute COVID-19 syndrome and to highlight potential correlations between their severity and multiple clinical and laboratory parameters. (2) Methods: In total, 121 women were included in our study, all of whom were younger than 55 and had been diagnosed with post-COVID-19 syndrome. Of those women, 67 also had metabolic syndrome (MS) (group A), whereas the other 54 did not (group B); 40 age-matched healthy subjects were used as controls (group C). (3) Results: Patients in group A had worse values of indexes characterizing AS and AoS and had more frequent DD compared to those from group B and group C (p < 0.0001). The statistical analysis evidenced significant associations between these indexes and the time that had elapsed since COVID-19 diagnosis, the factors that characterize the severity of the acute disease and those that specify MS. Multivariate regression analysis identified the following as the main independent predictors for DD: values of the AoS index, the C-reactive protein, and the triglyceride–glucose index. (4) Conclusions: Altered AS, AoS, and DD are common in patients with post-COVID-19 syndrome, especially with concurrent MS, and these parameters are apparently associated not only with the severity and time elapsed since COVID-19 diagnosis but also with MS.
format Online
Article
Text
id pubmed-9953636
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99536362023-02-25 Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome Tudoran, Cristina Bende, Felix Bende, Renata Giurgi-Oncu, Catalina Dumache, Raluca Tudoran, Mariana Biomedicines Article (1) Background: Abnormally increased arterial and aortic stiffness (AS and AoS), which are often associated with diastolic dysfunction (DD), represent common alterations in COVID-19. In this study, we aimed to assess, by transthoracic echocardiography (TTE) and pulse-wave velocity (PWV), the frequency of these dysfunctions in patients with post-acute COVID-19 syndrome and to highlight potential correlations between their severity and multiple clinical and laboratory parameters. (2) Methods: In total, 121 women were included in our study, all of whom were younger than 55 and had been diagnosed with post-COVID-19 syndrome. Of those women, 67 also had metabolic syndrome (MS) (group A), whereas the other 54 did not (group B); 40 age-matched healthy subjects were used as controls (group C). (3) Results: Patients in group A had worse values of indexes characterizing AS and AoS and had more frequent DD compared to those from group B and group C (p < 0.0001). The statistical analysis evidenced significant associations between these indexes and the time that had elapsed since COVID-19 diagnosis, the factors that characterize the severity of the acute disease and those that specify MS. Multivariate regression analysis identified the following as the main independent predictors for DD: values of the AoS index, the C-reactive protein, and the triglyceride–glucose index. (4) Conclusions: Altered AS, AoS, and DD are common in patients with post-COVID-19 syndrome, especially with concurrent MS, and these parameters are apparently associated not only with the severity and time elapsed since COVID-19 diagnosis but also with MS. MDPI 2023-02-08 /pmc/articles/PMC9953636/ /pubmed/36831027 http://dx.doi.org/10.3390/biomedicines11020492 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tudoran, Cristina
Bende, Felix
Bende, Renata
Giurgi-Oncu, Catalina
Dumache, Raluca
Tudoran, Mariana
Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title_full Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title_fullStr Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title_full_unstemmed Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title_short Correspondence between Aortic and Arterial Stiffness, and Diastolic Dysfunction in Apparently Healthy Female Patients with Post-Acute COVID-19 Syndrome
title_sort correspondence between aortic and arterial stiffness, and diastolic dysfunction in apparently healthy female patients with post-acute covid-19 syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953636/
https://www.ncbi.nlm.nih.gov/pubmed/36831027
http://dx.doi.org/10.3390/biomedicines11020492
work_keys_str_mv AT tudorancristina correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome
AT bendefelix correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome
AT benderenata correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome
AT giurgioncucatalina correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome
AT dumacheraluca correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome
AT tudoranmariana correspondencebetweenaorticandarterialstiffnessanddiastolicdysfunctioninapparentlyhealthyfemalepatientswithpostacutecovid19syndrome