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A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations
Tryptophan is an essential amino acid and a precursor of a number of physiologically important metabolites, including serotonin, melatonin, tryptamine, and kynurenines. We assessed tryptophan, kynurenines, and vitamin B2 and B6, as well as biomarkers of liver function and inflammation, in a group of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953657/ https://www.ncbi.nlm.nih.gov/pubmed/36830760 http://dx.doi.org/10.3390/biom13020391 |
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author | Bjørke-Monsen, Anne-Lise Varsi, Kristin Ulvik, Arve Sakkestad, Sunniva Todnem Ueland, Per Magne |
author_facet | Bjørke-Monsen, Anne-Lise Varsi, Kristin Ulvik, Arve Sakkestad, Sunniva Todnem Ueland, Per Magne |
author_sort | Bjørke-Monsen, Anne-Lise |
collection | PubMed |
description | Tryptophan is an essential amino acid and a precursor of a number of physiologically important metabolites, including serotonin, melatonin, tryptamine, and kynurenines. We assessed tryptophan, kynurenines, and vitamin B2 and B6, as well as biomarkers of liver function and inflammation, in a group of 158 female omnivores and vegetarians aged 18–40 years. The majority of women were omnivores, and 22% were vegetarians. Vegetarians had 25% lower serum ALT, significantly higher pyridoxal concentrations, and significantly lower plasma concentrations of most kynurenines, varying from 8% lower concentrations of median plasma kynurenine to 42% lower concentrations of plasma xanthurenic acid, compared to omnivores. No significant differences were observed in vitamin B2 status or in inflammation markers, C-reactive protein and neopterin between the groups. Vegetarians had lower levels of several plasma kynurenines compared to omnivores. The reason for this is unknown; however, lower ALT concentrations, suggesting a better liver status, and a more favourable vitamin B6 status might be contributing factors. |
format | Online Article Text |
id | pubmed-9953657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99536572023-02-25 A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations Bjørke-Monsen, Anne-Lise Varsi, Kristin Ulvik, Arve Sakkestad, Sunniva Todnem Ueland, Per Magne Biomolecules Article Tryptophan is an essential amino acid and a precursor of a number of physiologically important metabolites, including serotonin, melatonin, tryptamine, and kynurenines. We assessed tryptophan, kynurenines, and vitamin B2 and B6, as well as biomarkers of liver function and inflammation, in a group of 158 female omnivores and vegetarians aged 18–40 years. The majority of women were omnivores, and 22% were vegetarians. Vegetarians had 25% lower serum ALT, significantly higher pyridoxal concentrations, and significantly lower plasma concentrations of most kynurenines, varying from 8% lower concentrations of median plasma kynurenine to 42% lower concentrations of plasma xanthurenic acid, compared to omnivores. No significant differences were observed in vitamin B2 status or in inflammation markers, C-reactive protein and neopterin between the groups. Vegetarians had lower levels of several plasma kynurenines compared to omnivores. The reason for this is unknown; however, lower ALT concentrations, suggesting a better liver status, and a more favourable vitamin B6 status might be contributing factors. MDPI 2023-02-18 /pmc/articles/PMC9953657/ /pubmed/36830760 http://dx.doi.org/10.3390/biom13020391 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bjørke-Monsen, Anne-Lise Varsi, Kristin Ulvik, Arve Sakkestad, Sunniva Todnem Ueland, Per Magne A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title | A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title_full | A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title_fullStr | A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title_full_unstemmed | A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title_short | A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations |
title_sort | vegetarian diet significantly changes plasma kynurenine concentrations |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953657/ https://www.ncbi.nlm.nih.gov/pubmed/36830760 http://dx.doi.org/10.3390/biom13020391 |
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