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TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD

The airway epithelium, through pattern recognition receptors expressed transmembrane or intracellularly, acts as a first line of defense for the lungs against many environmental triggers. It is involved in the release of alarmin cytokines, which are important mediators of inflammation, with receptor...

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Autores principales: Furci, Fabiana, Murdaca, Giuseppe, Pelaia, Corrado, Imbalzano, Egidio, Pelaia, Girolamo, Caminati, Marco, Allegra, Alessandro, Senna, Gianenrico, Gangemi, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953666/
https://www.ncbi.nlm.nih.gov/pubmed/36830972
http://dx.doi.org/10.3390/biomedicines11020437
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author Furci, Fabiana
Murdaca, Giuseppe
Pelaia, Corrado
Imbalzano, Egidio
Pelaia, Girolamo
Caminati, Marco
Allegra, Alessandro
Senna, Gianenrico
Gangemi, Sebastiano
author_facet Furci, Fabiana
Murdaca, Giuseppe
Pelaia, Corrado
Imbalzano, Egidio
Pelaia, Girolamo
Caminati, Marco
Allegra, Alessandro
Senna, Gianenrico
Gangemi, Sebastiano
author_sort Furci, Fabiana
collection PubMed
description The airway epithelium, through pattern recognition receptors expressed transmembrane or intracellularly, acts as a first line of defense for the lungs against many environmental triggers. It is involved in the release of alarmin cytokines, which are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Knowledge of the role of epithelial cells in orchestrating the immune response and mediating the clearance of invading pathogens and dead/damaged cells to facilitate resolution of inflammation is necessary to understand how, in many chronic lung diseases, there is a persistent inflammatory response that becomes the basis of underlying pathogenesis. This review will focus on the role of pulmonary epithelial cells and of airway epithelial cell alarmins, in particular thymic stromal lymphopoietin (TSLP) and high mobility group box 1 (HMGB1), as key mediators in driving the inflammation of chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), evaluating the similarities and differences. Moreover, emerging concepts regarding the therapeutic role of molecules that act on airway epithelial cell alarmins will be explored for a precision medicine approach in the context of pulmonary diseases, thus allowing the use of these molecules as possible predictive biomarkers of clinical and biological response.
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spelling pubmed-99536662023-02-25 TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD Furci, Fabiana Murdaca, Giuseppe Pelaia, Corrado Imbalzano, Egidio Pelaia, Girolamo Caminati, Marco Allegra, Alessandro Senna, Gianenrico Gangemi, Sebastiano Biomedicines Review The airway epithelium, through pattern recognition receptors expressed transmembrane or intracellularly, acts as a first line of defense for the lungs against many environmental triggers. It is involved in the release of alarmin cytokines, which are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells. Knowledge of the role of epithelial cells in orchestrating the immune response and mediating the clearance of invading pathogens and dead/damaged cells to facilitate resolution of inflammation is necessary to understand how, in many chronic lung diseases, there is a persistent inflammatory response that becomes the basis of underlying pathogenesis. This review will focus on the role of pulmonary epithelial cells and of airway epithelial cell alarmins, in particular thymic stromal lymphopoietin (TSLP) and high mobility group box 1 (HMGB1), as key mediators in driving the inflammation of chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), evaluating the similarities and differences. Moreover, emerging concepts regarding the therapeutic role of molecules that act on airway epithelial cell alarmins will be explored for a precision medicine approach in the context of pulmonary diseases, thus allowing the use of these molecules as possible predictive biomarkers of clinical and biological response. MDPI 2023-02-02 /pmc/articles/PMC9953666/ /pubmed/36830972 http://dx.doi.org/10.3390/biomedicines11020437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Furci, Fabiana
Murdaca, Giuseppe
Pelaia, Corrado
Imbalzano, Egidio
Pelaia, Girolamo
Caminati, Marco
Allegra, Alessandro
Senna, Gianenrico
Gangemi, Sebastiano
TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title_full TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title_fullStr TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title_full_unstemmed TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title_short TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD
title_sort tslp and hmgb1: inflammatory targets and potential biomarkers for precision medicine in asthma and copd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953666/
https://www.ncbi.nlm.nih.gov/pubmed/36830972
http://dx.doi.org/10.3390/biomedicines11020437
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