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The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients
The altered cerebral energy metabolism central to schizophrenia can be linked to lactate accumulation. Lactic acid is produced by gastrointestinal bacteria, among others, and readily crosses the blood–brain barrier, leading to the brain acidity. This study aimed to examine the association of the ora...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953675/ https://www.ncbi.nlm.nih.gov/pubmed/36830777 http://dx.doi.org/10.3390/biomedicines11020240 |
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author | Krzyściak, Wirginia Karcz, Paulina Bystrowska, Beata Szwajca, Marta Bryll, Amira Śmierciak, Natalia Ligęzka, Anna Turek, Aleksander Kozicz, Tamas Skalniak, Anna E. Jagielski, Paweł Popiela, Tadeusz J. Pilecki, Maciej |
author_facet | Krzyściak, Wirginia Karcz, Paulina Bystrowska, Beata Szwajca, Marta Bryll, Amira Śmierciak, Natalia Ligęzka, Anna Turek, Aleksander Kozicz, Tamas Skalniak, Anna E. Jagielski, Paweł Popiela, Tadeusz J. Pilecki, Maciej |
author_sort | Krzyściak, Wirginia |
collection | PubMed |
description | The altered cerebral energy metabolism central to schizophrenia can be linked to lactate accumulation. Lactic acid is produced by gastrointestinal bacteria, among others, and readily crosses the blood–brain barrier, leading to the brain acidity. This study aimed to examine the association of the oral microbiota with the effects of acid stress induced by an increase of brain lactate in schizophrenia patients. The study included patients with a diagnosis of acute polyphasic psychotic disorder meeting criteria for schizophrenia at 3-month follow-up. Results: Individuals with a significantly higher total score on the Positive and Negative Syndrome Scale had statistically significantly lower lactate concentrations compared to those with a lower total score and higher brain lactate. We observed a positive correlation between Actinomyces and lactate levels in the anterior cingulate cap and a negative correlation between bacteria associated with lactate metabolism and some clinical assessment scales. Conclusions: Shifts in the oral microbiota in favour of lactate-utilising bacterial genera may represent a compensatory mechanism in response to increased lactate production in the brain. Assessment of neuronal function mediated by ALA-LAC-dependent NMDA regulatory mechanisms may, thus, support new therapies for schizophrenia, for which acidosis has become a differentiating feature of individuals with schizophrenia endophenotypes. |
format | Online Article Text |
id | pubmed-9953675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99536752023-02-25 The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients Krzyściak, Wirginia Karcz, Paulina Bystrowska, Beata Szwajca, Marta Bryll, Amira Śmierciak, Natalia Ligęzka, Anna Turek, Aleksander Kozicz, Tamas Skalniak, Anna E. Jagielski, Paweł Popiela, Tadeusz J. Pilecki, Maciej Biomedicines Article The altered cerebral energy metabolism central to schizophrenia can be linked to lactate accumulation. Lactic acid is produced by gastrointestinal bacteria, among others, and readily crosses the blood–brain barrier, leading to the brain acidity. This study aimed to examine the association of the oral microbiota with the effects of acid stress induced by an increase of brain lactate in schizophrenia patients. The study included patients with a diagnosis of acute polyphasic psychotic disorder meeting criteria for schizophrenia at 3-month follow-up. Results: Individuals with a significantly higher total score on the Positive and Negative Syndrome Scale had statistically significantly lower lactate concentrations compared to those with a lower total score and higher brain lactate. We observed a positive correlation between Actinomyces and lactate levels in the anterior cingulate cap and a negative correlation between bacteria associated with lactate metabolism and some clinical assessment scales. Conclusions: Shifts in the oral microbiota in favour of lactate-utilising bacterial genera may represent a compensatory mechanism in response to increased lactate production in the brain. Assessment of neuronal function mediated by ALA-LAC-dependent NMDA regulatory mechanisms may, thus, support new therapies for schizophrenia, for which acidosis has become a differentiating feature of individuals with schizophrenia endophenotypes. MDPI 2023-01-17 /pmc/articles/PMC9953675/ /pubmed/36830777 http://dx.doi.org/10.3390/biomedicines11020240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Krzyściak, Wirginia Karcz, Paulina Bystrowska, Beata Szwajca, Marta Bryll, Amira Śmierciak, Natalia Ligęzka, Anna Turek, Aleksander Kozicz, Tamas Skalniak, Anna E. Jagielski, Paweł Popiela, Tadeusz J. Pilecki, Maciej The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title | The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title_full | The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title_fullStr | The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title_full_unstemmed | The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title_short | The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients |
title_sort | association of the oral microbiota with the effects of acid stress induced by an increase of brain lactate in schizophrenia patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953675/ https://www.ncbi.nlm.nih.gov/pubmed/36830777 http://dx.doi.org/10.3390/biomedicines11020240 |
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