Cargando…
The Role of Pericytes in Regulation of Innate and Adaptive Immunity
Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow. However, recent evidence suggests that in addition to traditionally credited structural function, pericytes also m...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953719/ https://www.ncbi.nlm.nih.gov/pubmed/36831136 http://dx.doi.org/10.3390/biomedicines11020600 |
_version_ | 1784893947785510912 |
---|---|
author | Dabravolski, Siarhei A. Andreeva, Elena R. Eremin, Ilya I. Markin, Alexander M. Nadelyaeva, Irina I. Orekhov, Alexander N. Melnichenko, Alexandra A. |
author_facet | Dabravolski, Siarhei A. Andreeva, Elena R. Eremin, Ilya I. Markin, Alexander M. Nadelyaeva, Irina I. Orekhov, Alexander N. Melnichenko, Alexandra A. |
author_sort | Dabravolski, Siarhei A. |
collection | PubMed |
description | Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow. However, recent evidence suggests that in addition to traditionally credited structural function, pericytes also manifest immune properties. In this review, we summarise recent data regarding pericytes’ response to different pro-inflammatory stimuli and their involvement in innate immune responses through expression of pattern-recognition receptors. Moreover, pericytes express various adhesion molecules, thus regulating trafficking of immune cells across vessel walls. Additionally, the role of pericytes in modulation of adaptive immunity is discussed. Finally, recent reports have suggested that the interaction with cancer cells evokes immunosuppression function in pericytes, thus facilitating immune evasion and facilitating cancer proliferation and metastasis. However, such complex and multi-faceted cross-talks of pericytes with immune cells also suggest a number of potential pericyte-based therapeutic methods and techniques for cancer immunotherapy and treatment of autoimmune and auto-inflammatory disorders. |
format | Online Article Text |
id | pubmed-9953719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99537192023-02-25 The Role of Pericytes in Regulation of Innate and Adaptive Immunity Dabravolski, Siarhei A. Andreeva, Elena R. Eremin, Ilya I. Markin, Alexander M. Nadelyaeva, Irina I. Orekhov, Alexander N. Melnichenko, Alexandra A. Biomedicines Review Pericytes are perivascular multipotent cells wrapping microvascular capillaries, where they support vasculature functioning, participate in tissue regeneration, and regulate blood flow. However, recent evidence suggests that in addition to traditionally credited structural function, pericytes also manifest immune properties. In this review, we summarise recent data regarding pericytes’ response to different pro-inflammatory stimuli and their involvement in innate immune responses through expression of pattern-recognition receptors. Moreover, pericytes express various adhesion molecules, thus regulating trafficking of immune cells across vessel walls. Additionally, the role of pericytes in modulation of adaptive immunity is discussed. Finally, recent reports have suggested that the interaction with cancer cells evokes immunosuppression function in pericytes, thus facilitating immune evasion and facilitating cancer proliferation and metastasis. However, such complex and multi-faceted cross-talks of pericytes with immune cells also suggest a number of potential pericyte-based therapeutic methods and techniques for cancer immunotherapy and treatment of autoimmune and auto-inflammatory disorders. MDPI 2023-02-17 /pmc/articles/PMC9953719/ /pubmed/36831136 http://dx.doi.org/10.3390/biomedicines11020600 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dabravolski, Siarhei A. Andreeva, Elena R. Eremin, Ilya I. Markin, Alexander M. Nadelyaeva, Irina I. Orekhov, Alexander N. Melnichenko, Alexandra A. The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title | The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title_full | The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title_fullStr | The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title_full_unstemmed | The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title_short | The Role of Pericytes in Regulation of Innate and Adaptive Immunity |
title_sort | role of pericytes in regulation of innate and adaptive immunity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953719/ https://www.ncbi.nlm.nih.gov/pubmed/36831136 http://dx.doi.org/10.3390/biomedicines11020600 |
work_keys_str_mv | AT dabravolskisiarheia theroleofpericytesinregulationofinnateandadaptiveimmunity AT andreevaelenar theroleofpericytesinregulationofinnateandadaptiveimmunity AT ereminilyai theroleofpericytesinregulationofinnateandadaptiveimmunity AT markinalexanderm theroleofpericytesinregulationofinnateandadaptiveimmunity AT nadelyaevairinai theroleofpericytesinregulationofinnateandadaptiveimmunity AT orekhovalexandern theroleofpericytesinregulationofinnateandadaptiveimmunity AT melnichenkoalexandraa theroleofpericytesinregulationofinnateandadaptiveimmunity AT dabravolskisiarheia roleofpericytesinregulationofinnateandadaptiveimmunity AT andreevaelenar roleofpericytesinregulationofinnateandadaptiveimmunity AT ereminilyai roleofpericytesinregulationofinnateandadaptiveimmunity AT markinalexanderm roleofpericytesinregulationofinnateandadaptiveimmunity AT nadelyaevairinai roleofpericytesinregulationofinnateandadaptiveimmunity AT orekhovalexandern roleofpericytesinregulationofinnateandadaptiveimmunity AT melnichenkoalexandraa roleofpericytesinregulationofinnateandadaptiveimmunity |