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Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder

Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers and oxidative stress and evaluated the effects of the Mediterranean Diet (MD) in modulating these markers. Me...

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Autores principales: Cirillo, Michela, Argento, Flavia Rita, Attanasio, Monica, Becatti, Matteo, Ladisa, Irene, Fiorillo, Claudia, Coccia, Maria Elisabetta, Fatini, Cinzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953736/
https://www.ncbi.nlm.nih.gov/pubmed/36830986
http://dx.doi.org/10.3390/biomedicines11020450
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author Cirillo, Michela
Argento, Flavia Rita
Attanasio, Monica
Becatti, Matteo
Ladisa, Irene
Fiorillo, Claudia
Coccia, Maria Elisabetta
Fatini, Cinzia
author_facet Cirillo, Michela
Argento, Flavia Rita
Attanasio, Monica
Becatti, Matteo
Ladisa, Irene
Fiorillo, Claudia
Coccia, Maria Elisabetta
Fatini, Cinzia
author_sort Cirillo, Michela
collection PubMed
description Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers and oxidative stress and evaluated the effects of the Mediterranean Diet (MD) in modulating these markers. Methods: In this prospective study, we included 35 women with endometriosis. At baseline (T0) and after 3 (T1) and 6 (T2) months from the start of the diet, we investigated cardiometabolic parameters, lifestyle and oxidative stress. Results: After a 3-month intervention with MD, we observed a significant reduction in total cholesterol (p = 0.01) and LDL-c (p = 0.003). We observed at T1 an increase in B12 and E vitamins, folate and zinc. After 6 months, zinc (p = 0.04) and folate (p = 0.08) increased in comparison to T0. A reduction in homocysteine from T0 to T1 (p = 0.01) was found. After 3 months, an increase in Rapid Assessment of Physical Activity tool 1 (RAPA) (p < 0.001) and RAPA 2 was observed (p = 0.009). We observed high levels of oxidative stress markers at baseline. After 6 months of MD, a significant improvement in lymphocyte Reactive Oxygen Species (ROS) (p < 0.001) and total antioxidant capacity was observed (p = 0.02). Conclusions: The improvement of lifestyle, and in particular the Mediterranean dietary intervention, allowed the improvement of the metabolic and oxidative profile and overall health-related quality of life.
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spelling pubmed-99537362023-02-25 Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder Cirillo, Michela Argento, Flavia Rita Attanasio, Monica Becatti, Matteo Ladisa, Irene Fiorillo, Claudia Coccia, Maria Elisabetta Fatini, Cinzia Biomedicines Article Background: Accelerated atherosclerosis in patients with endometriosis has been hypothesised, and lifestyle improvement might control cardiovascular risk. We explored cardiometabolic markers and oxidative stress and evaluated the effects of the Mediterranean Diet (MD) in modulating these markers. Methods: In this prospective study, we included 35 women with endometriosis. At baseline (T0) and after 3 (T1) and 6 (T2) months from the start of the diet, we investigated cardiometabolic parameters, lifestyle and oxidative stress. Results: After a 3-month intervention with MD, we observed a significant reduction in total cholesterol (p = 0.01) and LDL-c (p = 0.003). We observed at T1 an increase in B12 and E vitamins, folate and zinc. After 6 months, zinc (p = 0.04) and folate (p = 0.08) increased in comparison to T0. A reduction in homocysteine from T0 to T1 (p = 0.01) was found. After 3 months, an increase in Rapid Assessment of Physical Activity tool 1 (RAPA) (p < 0.001) and RAPA 2 was observed (p = 0.009). We observed high levels of oxidative stress markers at baseline. After 6 months of MD, a significant improvement in lymphocyte Reactive Oxygen Species (ROS) (p < 0.001) and total antioxidant capacity was observed (p = 0.02). Conclusions: The improvement of lifestyle, and in particular the Mediterranean dietary intervention, allowed the improvement of the metabolic and oxidative profile and overall health-related quality of life. MDPI 2023-02-03 /pmc/articles/PMC9953736/ /pubmed/36830986 http://dx.doi.org/10.3390/biomedicines11020450 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cirillo, Michela
Argento, Flavia Rita
Attanasio, Monica
Becatti, Matteo
Ladisa, Irene
Fiorillo, Claudia
Coccia, Maria Elisabetta
Fatini, Cinzia
Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title_full Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title_fullStr Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title_full_unstemmed Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title_short Atherosclerosis and Endometriosis: The Role of Diet and Oxidative Stress in a Gender-Specific Disorder
title_sort atherosclerosis and endometriosis: the role of diet and oxidative stress in a gender-specific disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953736/
https://www.ncbi.nlm.nih.gov/pubmed/36830986
http://dx.doi.org/10.3390/biomedicines11020450
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