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Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management

The ever-increasing number of cancer cases and persistently high mortality underlines the urgent need to acquire new perspectives for developing innovative therapeutic approaches. As the research on protein-coding genes brought significant yet only incremental progress in the development of anticanc...

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Autores principales: Szczepaniak, Adrian, Bronisz, Agnieszka, Godlewski, Jakub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953808/
https://www.ncbi.nlm.nih.gov/pubmed/36831219
http://dx.doi.org/10.3390/cells12040552
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author Szczepaniak, Adrian
Bronisz, Agnieszka
Godlewski, Jakub
author_facet Szczepaniak, Adrian
Bronisz, Agnieszka
Godlewski, Jakub
author_sort Szczepaniak, Adrian
collection PubMed
description The ever-increasing number of cancer cases and persistently high mortality underlines the urgent need to acquire new perspectives for developing innovative therapeutic approaches. As the research on protein-coding genes brought significant yet only incremental progress in the development of anticancer therapy, much attention is now devoted to understanding the role of non-coding RNAs (ncRNAs) in various types of cancer. Recent years have brought about the awareness that ncRNAs recognized previously as “dark matter” are, in fact, key players in shaping cancer development. Moreover, breakthrough discoveries concerning the role of a new group of ncRNAs, circular RNAs, have evidenced their high importance in many diseases, including malignancies. Therefore, in the following review, we focus on the role of circular RNAs in cancer, particularly in cancer stem-like cells, summarize their mechanisms of action, and provide an overview of the state-of-the-art toolkits to study them.
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spelling pubmed-99538082023-02-25 Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management Szczepaniak, Adrian Bronisz, Agnieszka Godlewski, Jakub Cells Review The ever-increasing number of cancer cases and persistently high mortality underlines the urgent need to acquire new perspectives for developing innovative therapeutic approaches. As the research on protein-coding genes brought significant yet only incremental progress in the development of anticancer therapy, much attention is now devoted to understanding the role of non-coding RNAs (ncRNAs) in various types of cancer. Recent years have brought about the awareness that ncRNAs recognized previously as “dark matter” are, in fact, key players in shaping cancer development. Moreover, breakthrough discoveries concerning the role of a new group of ncRNAs, circular RNAs, have evidenced their high importance in many diseases, including malignancies. Therefore, in the following review, we focus on the role of circular RNAs in cancer, particularly in cancer stem-like cells, summarize their mechanisms of action, and provide an overview of the state-of-the-art toolkits to study them. MDPI 2023-02-08 /pmc/articles/PMC9953808/ /pubmed/36831219 http://dx.doi.org/10.3390/cells12040552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szczepaniak, Adrian
Bronisz, Agnieszka
Godlewski, Jakub
Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title_full Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title_fullStr Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title_full_unstemmed Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title_short Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management
title_sort circular rnas—new kids on the block in cancer pathophysiology and management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953808/
https://www.ncbi.nlm.nih.gov/pubmed/36831219
http://dx.doi.org/10.3390/cells12040552
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