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Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

SIMPLE SUMMARY: Clear cell renal cell carcinoma (ccRCC) progression, which is the most common form of kidney cancer, is associated with the loss of the Von Hippel-Lindau (VHL) gene in renal epithelium. VHL promotes proteasomal degradation of Hypoxia Inducible Factor alpha (HIF-α) thereby inhibiting...

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Detalles Bibliográficos
Autores principales:	Mazumder, Sonia, Higgins, Paul J., Samarakoon, Rohan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953937/ https://www.ncbi.nlm.nih.gov/pubmed/36831657 http://dx.doi.org/10.3390/cancers15041316

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