Cargando…

Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors

We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M...

Descripción completa

Detalles Bibliográficos
Autores principales: Vokhmyanina, Darya, Daboss, Elena, Sharapova, Olesya, Mogilnikova, Mariia, Karyakin, Arkady
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953944/
https://www.ncbi.nlm.nih.gov/pubmed/36832015
http://dx.doi.org/10.3390/bios13020250
_version_ 1784894003705020416
author Vokhmyanina, Darya
Daboss, Elena
Sharapova, Olesya
Mogilnikova, Mariia
Karyakin, Arkady
author_facet Vokhmyanina, Darya
Daboss, Elena
Sharapova, Olesya
Mogilnikova, Mariia
Karyakin, Arkady
author_sort Vokhmyanina, Darya
collection PubMed
description We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M) and an approximately four times lower detection limit versus the surface-modified sensors due to the dramatically decreased noise resulting in, on average, a six times higher signal-to-noise ratio. The corresponding glucose and lactate biosensors demonstrated similar and even higher sensitivities compared to those of biosensors based on surface-modified transducers. The biosensors have been validated through analysis of human serum. The decreased time and cost for production of single printing step bulk-modified transducers, as well as their analytical performance characteristics, which are advantageous over conventional surface-modified ones, would be expected to enable their wide use in (bio)sensorics.
format Online
Article
Text
id pubmed-9953944
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99539442023-02-25 Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors Vokhmyanina, Darya Daboss, Elena Sharapova, Olesya Mogilnikova, Mariia Karyakin, Arkady Biosensors (Basel) Article We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M) and an approximately four times lower detection limit versus the surface-modified sensors due to the dramatically decreased noise resulting in, on average, a six times higher signal-to-noise ratio. The corresponding glucose and lactate biosensors demonstrated similar and even higher sensitivities compared to those of biosensors based on surface-modified transducers. The biosensors have been validated through analysis of human serum. The decreased time and cost for production of single printing step bulk-modified transducers, as well as their analytical performance characteristics, which are advantageous over conventional surface-modified ones, would be expected to enable their wide use in (bio)sensorics. MDPI 2023-02-09 /pmc/articles/PMC9953944/ /pubmed/36832015 http://dx.doi.org/10.3390/bios13020250 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vokhmyanina, Darya
Daboss, Elena
Sharapova, Olesya
Mogilnikova, Mariia
Karyakin, Arkady
Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title_full Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title_fullStr Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title_full_unstemmed Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title_short Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
title_sort single printing step prussian blue bulk-modified transducers for oxidase-based biosensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953944/
https://www.ncbi.nlm.nih.gov/pubmed/36832015
http://dx.doi.org/10.3390/bios13020250
work_keys_str_mv AT vokhmyaninadarya singleprintingstepprussianbluebulkmodifiedtransducersforoxidasebasedbiosensors
AT dabosselena singleprintingstepprussianbluebulkmodifiedtransducersforoxidasebasedbiosensors
AT sharapovaolesya singleprintingstepprussianbluebulkmodifiedtransducersforoxidasebasedbiosensors
AT mogilnikovamariia singleprintingstepprussianbluebulkmodifiedtransducersforoxidasebasedbiosensors
AT karyakinarkady singleprintingstepprussianbluebulkmodifiedtransducersforoxidasebasedbiosensors