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Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors
We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953944/ https://www.ncbi.nlm.nih.gov/pubmed/36832015 http://dx.doi.org/10.3390/bios13020250 |
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author | Vokhmyanina, Darya Daboss, Elena Sharapova, Olesya Mogilnikova, Mariia Karyakin, Arkady |
author_facet | Vokhmyanina, Darya Daboss, Elena Sharapova, Olesya Mogilnikova, Mariia Karyakin, Arkady |
author_sort | Vokhmyanina, Darya |
collection | PubMed |
description | We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M) and an approximately four times lower detection limit versus the surface-modified sensors due to the dramatically decreased noise resulting in, on average, a six times higher signal-to-noise ratio. The corresponding glucose and lactate biosensors demonstrated similar and even higher sensitivities compared to those of biosensors based on surface-modified transducers. The biosensors have been validated through analysis of human serum. The decreased time and cost for production of single printing step bulk-modified transducers, as well as their analytical performance characteristics, which are advantageous over conventional surface-modified ones, would be expected to enable their wide use in (bio)sensorics. |
format | Online Article Text |
id | pubmed-9953944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99539442023-02-25 Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors Vokhmyanina, Darya Daboss, Elena Sharapova, Olesya Mogilnikova, Mariia Karyakin, Arkady Biosensors (Basel) Article We report on hydrogen peroxide sensors made through a single printing step with carbon ink containing catalytically synthesized Prussian blue nanoparticles. Despite their reduced sensitivity, the resulting bulk-modified sensors displayed both a wider linear calibration range (5 × 10(−7)–1 × 10(−3) M) and an approximately four times lower detection limit versus the surface-modified sensors due to the dramatically decreased noise resulting in, on average, a six times higher signal-to-noise ratio. The corresponding glucose and lactate biosensors demonstrated similar and even higher sensitivities compared to those of biosensors based on surface-modified transducers. The biosensors have been validated through analysis of human serum. The decreased time and cost for production of single printing step bulk-modified transducers, as well as their analytical performance characteristics, which are advantageous over conventional surface-modified ones, would be expected to enable their wide use in (bio)sensorics. MDPI 2023-02-09 /pmc/articles/PMC9953944/ /pubmed/36832015 http://dx.doi.org/10.3390/bios13020250 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vokhmyanina, Darya Daboss, Elena Sharapova, Olesya Mogilnikova, Mariia Karyakin, Arkady Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title | Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title_full | Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title_fullStr | Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title_full_unstemmed | Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title_short | Single Printing Step Prussian Blue Bulk-Modified Transducers for Oxidase-Based Biosensors |
title_sort | single printing step prussian blue bulk-modified transducers for oxidase-based biosensors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953944/ https://www.ncbi.nlm.nih.gov/pubmed/36832015 http://dx.doi.org/10.3390/bios13020250 |
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