Cargando…
Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri
Pseudotumor cerebri (PTC) in children is a rare condition whose underlying cause remains largely unknown. No study has yet systematically examined viral infection as a cause of PTC. The current study aimed to characterize PTC in children and investigate the possible role of acute viral infection of...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953968/ https://www.ncbi.nlm.nih.gov/pubmed/36831904 http://dx.doi.org/10.3390/brainsci13020361 |
_version_ | 1784894009843384320 |
---|---|
author | Cohen, Rony Mahajnah, Muhammad Shlonsky, Yulia Golan-Shany, Orit Romem, Azriel Halevy, Ayelet Natan, Keren Genizi, Jacob |
author_facet | Cohen, Rony Mahajnah, Muhammad Shlonsky, Yulia Golan-Shany, Orit Romem, Azriel Halevy, Ayelet Natan, Keren Genizi, Jacob |
author_sort | Cohen, Rony |
collection | PubMed |
description | Pseudotumor cerebri (PTC) in children is a rare condition whose underlying cause remains largely unknown. No study has yet systematically examined viral infection as a cause of PTC. The current study aimed to characterize PTC in children and investigate the possible role of acute viral infection of the central nervous system in its pathogenesis. A prospective, cross-sectional study was conducted in three centers in Israel. Participants were 50 children aged 0.5–18 years, of whom 27 had a definitive diagnosis of pseudotumor cerebri (the study group) and 23 comprised a control. Data collected included clinical presentation, imaging, treatment, ophthalmic findings, and cerebrospinal fluid (CSF) analysis. Using the ALLPLEX(TM) meningitis panel, real-time polymerase chain reaction (PCR) was used to test for the presence of 12 common viruses. PTC patients (mean age 12 ± 4.3 years; 14 males, 13 females) had mean opening pressure of 41.9 ±10.2 mmH2O. All PTC patients had papilledema, and 25 (93%) had PTC symptoms. No viruses were found in the PTC group, while in the control group, one patient tested positive for Epstein–Barr virus and another for human herpesvirus type 6. Overall, in our study, PTC was not found to be associated with the presence of viruses in CSF. |
format | Online Article Text |
id | pubmed-9953968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99539682023-02-25 Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri Cohen, Rony Mahajnah, Muhammad Shlonsky, Yulia Golan-Shany, Orit Romem, Azriel Halevy, Ayelet Natan, Keren Genizi, Jacob Brain Sci Communication Pseudotumor cerebri (PTC) in children is a rare condition whose underlying cause remains largely unknown. No study has yet systematically examined viral infection as a cause of PTC. The current study aimed to characterize PTC in children and investigate the possible role of acute viral infection of the central nervous system in its pathogenesis. A prospective, cross-sectional study was conducted in three centers in Israel. Participants were 50 children aged 0.5–18 years, of whom 27 had a definitive diagnosis of pseudotumor cerebri (the study group) and 23 comprised a control. Data collected included clinical presentation, imaging, treatment, ophthalmic findings, and cerebrospinal fluid (CSF) analysis. Using the ALLPLEX(TM) meningitis panel, real-time polymerase chain reaction (PCR) was used to test for the presence of 12 common viruses. PTC patients (mean age 12 ± 4.3 years; 14 males, 13 females) had mean opening pressure of 41.9 ±10.2 mmH2O. All PTC patients had papilledema, and 25 (93%) had PTC symptoms. No viruses were found in the PTC group, while in the control group, one patient tested positive for Epstein–Barr virus and another for human herpesvirus type 6. Overall, in our study, PTC was not found to be associated with the presence of viruses in CSF. MDPI 2023-02-19 /pmc/articles/PMC9953968/ /pubmed/36831904 http://dx.doi.org/10.3390/brainsci13020361 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Cohen, Rony Mahajnah, Muhammad Shlonsky, Yulia Golan-Shany, Orit Romem, Azriel Halevy, Ayelet Natan, Keren Genizi, Jacob Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title | Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title_full | Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title_fullStr | Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title_full_unstemmed | Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title_short | Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri |
title_sort | prospective, cross-sectional study finds no common viruses in cerebrospinal fluid of children with pseudotumor cerebri |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9953968/ https://www.ncbi.nlm.nih.gov/pubmed/36831904 http://dx.doi.org/10.3390/brainsci13020361 |
work_keys_str_mv | AT cohenrony prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT mahajnahmuhammad prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT shlonskyyulia prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT golanshanyorit prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT romemazriel prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT halevyayelet prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT natankeren prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri AT genizijacob prospectivecrosssectionalstudyfindsnocommonvirusesincerebrospinalfluidofchildrenwithpseudotumorcerebri |