Challenges and Therapeutic Opportunities in the dMMR/MSI-H Colorectal Cancer Landscape

SIMPLE SUMMARY: Between 5% and 15% of colorectal cancers (CRC) show deficiencies in the mismatch repair machinery and high microsatellite instability (dMMR/MSI-H). dMMR/MSI-H CRC is characterized by a dysfunctional DNA repair system, which renders the tumor immune microenvironment more susceptible t...

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Detalles Bibliográficos
Autores principales: Mulet-Margalef, Núria, Linares, Jenniffer, Badia-Ramentol, Jordi, Jimeno, Mireya, Sanz Monte, Carolina, Manzano Mozo, José Luis, Calon, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954007/
https://www.ncbi.nlm.nih.gov/pubmed/36831367
http://dx.doi.org/10.3390/cancers15041022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954007/
https://www.ncbi.nlm.nih.gov/pubmed/36831367
http://dx.doi.org/10.3390/cancers15041022

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