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Challenges and Therapeutic Opportunities in the dMMR/MSI-H Colorectal Cancer Landscape
SIMPLE SUMMARY: Between 5% and 15% of colorectal cancers (CRC) show deficiencies in the mismatch repair machinery and high microsatellite instability (dMMR/MSI-H). dMMR/MSI-H CRC is characterized by a dysfunctional DNA repair system, which renders the tumor immune microenvironment more susceptible t...
Autores principales: | Mulet-Margalef, Núria, Linares, Jenniffer, Badia-Ramentol, Jordi, Jimeno, Mireya, Sanz Monte, Carolina, Manzano Mozo, José Luis, Calon, Alexandre |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954007/ https://www.ncbi.nlm.nih.gov/pubmed/36831367 http://dx.doi.org/10.3390/cancers15041022 |
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