Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics

Cytoskeleton organization and dynamics are rapidly regulated by post-translational modifications of key target proteins. Acting downstream of the Cdc42 GTPase, the myotonic dystrophy-related Cdc42-binding kinases MRCKα, MRCKβ, and MRCKγ have recently emerged as important players in cytoskeleton regu...

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Detalles Bibliográficos
Autores principales: Ruscetta, Vanessa M., Seaton, Taj J., Shakeel, Aleen, Vasconcelos, Stanley N. S., Viirre, Russell D., Adler, Marc J., Olson, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954052/
https://www.ncbi.nlm.nih.gov/pubmed/36831201
http://dx.doi.org/10.3390/cells12040534

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