Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca(2+)-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). The enzymes inv...

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Detalles Bibliográficos
Autor principal: Guse, Andreas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954121/
https://www.ncbi.nlm.nih.gov/pubmed/36831342
http://dx.doi.org/10.3390/cells12040675
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author Guse, Andreas H.
author_facet Guse, Andreas H.
author_sort Guse, Andreas H.
collection PubMed
description Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca(2+)-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). The enzymes involved are either NAD glycohydrolases CD38 or sterile alpha toll/interleukin receptor motif containing-1 (SARM1), or (dual) NADPH oxidases (NOX/DUOX). Enzymatic function(s) are reviewed and physiological role(s) in selected cell systems are discussed.
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spelling pubmed-99541212023-02-25 Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases Guse, Andreas H. Cells Review Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca(2+)-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine dinucleotide phosphate (NAADP). The enzymes involved are either NAD glycohydrolases CD38 or sterile alpha toll/interleukin receptor motif containing-1 (SARM1), or (dual) NADPH oxidases (NOX/DUOX). Enzymatic function(s) are reviewed and physiological role(s) in selected cell systems are discussed. MDPI 2023-02-20 /pmc/articles/PMC9954121/ /pubmed/36831342 http://dx.doi.org/10.3390/cells12040675 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guse, Andreas H.
Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title_full Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title_fullStr Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title_full_unstemmed Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title_short Enzymology of Ca(2+)-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases
title_sort enzymology of ca(2+)-mobilizing second messengers derived from nad: from nad glycohydrolases to (dual) nadph oxidases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954121/
https://www.ncbi.nlm.nih.gov/pubmed/36831342
http://dx.doi.org/10.3390/cells12040675
work_keys_str_mv AT guseandreash enzymologyofca2mobilizingsecondmessengersderivedfromnadfromnadglycohydrolasestodualnadphoxidases

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