Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

SIMPLE SUMMARY: The hyaluronan receptor CD44 plays a vital role in tumor cell growth and chemotherapy resistance. The tumor suppressor p53 binds to the CD44 promoter via a non-canonical p53 consensus sequence and suppresses CD44 expression, promoting apoptosis. Conversely, the apoptotic function of...

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Detalles Bibliográficos
Autores principales: Lin, Chun-Yu, Basu, Kaustuv, Ruusala, Aino, Kozlova, Inna, Li, Yan-Shuang, Skandalis, Spyridon S., Heldin, Carl-Henrik, Heldin, Paraskevi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954134/
https://www.ncbi.nlm.nih.gov/pubmed/36831425
http://dx.doi.org/10.3390/cancers15041082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954134/
https://www.ncbi.nlm.nih.gov/pubmed/36831425
http://dx.doi.org/10.3390/cancers15041082

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