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In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening

The evolution of preclinical in vitro cancer models has led to the emergence of human cancer-on-chip or microphysiological analysis platforms (MAPs). Although it has numerous advantages compared to other models, cancer-on-chip technology still faces several challenges such as the complexity of the t...

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Autores principales: Ngo, Huyen, Amartumur, Sarnai, Tran, Van Thi Ai, Tran, Minh, Diep, Yen N., Cho, Hansang, Lee, Luke P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954135/
https://www.ncbi.nlm.nih.gov/pubmed/36831997
http://dx.doi.org/10.3390/bios13020231
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author Ngo, Huyen
Amartumur, Sarnai
Tran, Van Thi Ai
Tran, Minh
Diep, Yen N.
Cho, Hansang
Lee, Luke P.
author_facet Ngo, Huyen
Amartumur, Sarnai
Tran, Van Thi Ai
Tran, Minh
Diep, Yen N.
Cho, Hansang
Lee, Luke P.
author_sort Ngo, Huyen
collection PubMed
description The evolution of preclinical in vitro cancer models has led to the emergence of human cancer-on-chip or microphysiological analysis platforms (MAPs). Although it has numerous advantages compared to other models, cancer-on-chip technology still faces several challenges such as the complexity of the tumor microenvironment and integrating multiple organs to be widely accepted in cancer research and therapeutics. In this review, we highlight the advancements in cancer-on-chip technology in recapitulating the vital biological features of various cancer types and their applications in life sciences and high-throughput drug screening. We present advances in reconstituting the tumor microenvironment and modeling cancer stages in breast, brain, and other types of cancer. We also discuss the relevance of MAPs in cancer modeling and precision medicine such as effect of flow on cancer growth and the short culture period compared to clinics. The advanced MAPs provide high-throughput platforms with integrated biosensors to monitor real-time cellular responses applied in drug development. We envision that the integrated cancer MAPs has a promising future with regard to cancer research, including cancer biology, drug discovery, and personalized medicine.
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spelling pubmed-99541352023-02-25 In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening Ngo, Huyen Amartumur, Sarnai Tran, Van Thi Ai Tran, Minh Diep, Yen N. Cho, Hansang Lee, Luke P. Biosensors (Basel) Review The evolution of preclinical in vitro cancer models has led to the emergence of human cancer-on-chip or microphysiological analysis platforms (MAPs). Although it has numerous advantages compared to other models, cancer-on-chip technology still faces several challenges such as the complexity of the tumor microenvironment and integrating multiple organs to be widely accepted in cancer research and therapeutics. In this review, we highlight the advancements in cancer-on-chip technology in recapitulating the vital biological features of various cancer types and their applications in life sciences and high-throughput drug screening. We present advances in reconstituting the tumor microenvironment and modeling cancer stages in breast, brain, and other types of cancer. We also discuss the relevance of MAPs in cancer modeling and precision medicine such as effect of flow on cancer growth and the short culture period compared to clinics. The advanced MAPs provide high-throughput platforms with integrated biosensors to monitor real-time cellular responses applied in drug development. We envision that the integrated cancer MAPs has a promising future with regard to cancer research, including cancer biology, drug discovery, and personalized medicine. MDPI 2023-02-06 /pmc/articles/PMC9954135/ /pubmed/36831997 http://dx.doi.org/10.3390/bios13020231 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ngo, Huyen
Amartumur, Sarnai
Tran, Van Thi Ai
Tran, Minh
Diep, Yen N.
Cho, Hansang
Lee, Luke P.
In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title_full In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title_fullStr In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title_full_unstemmed In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title_short In Vitro Tumor Models on Chip and Integrated Microphysiological Analysis Platform (MAP) for Life Sciences and High-Throughput Drug Screening
title_sort in vitro tumor models on chip and integrated microphysiological analysis platform (map) for life sciences and high-throughput drug screening
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954135/
https://www.ncbi.nlm.nih.gov/pubmed/36831997
http://dx.doi.org/10.3390/bios13020231
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