Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson’s Disease Patient

Progressive accumulation of α-Synuclein (αSyn) in Lewy bodies (LBs) and loss of dopaminergic (DA) neurons are the hallmark pathological features of Parkinson’s disease (PD). Although currently available in vitro and in vivo models have provided crucial information about PD pathogenesis, the mechanis...

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Detalles Bibliográficos
Autores principales: Becerra-Calixto, Andrea, Mukherjee, Abhisek, Ramirez, Santiago, Sepulveda, Sofia, Sinha, Tirthankar, Al-Lahham, Rabab, De Gregorio, Nicole, Gherardelli, Camila, Soto, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954141/
https://www.ncbi.nlm.nih.gov/pubmed/36831291
http://dx.doi.org/10.3390/cells12040625

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