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Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease

Data linking heart rate variability (HRV) and cognitive status remains controversial and scarce, particularly in cerebral small vessel disease (CSVD) patients. Whether the association between HRV and cognitive performance exists in CSVD patients is unclear. Hence, we aimed to investigate the associa...

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Autores principales: Hu, Guoliang, Collet, Jean-Paul, Zhao, Mengxi, Lu, Yao, Wang, Yilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954276/
https://www.ncbi.nlm.nih.gov/pubmed/36831887
http://dx.doi.org/10.3390/brainsci13020344
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author Hu, Guoliang
Collet, Jean-Paul
Zhao, Mengxi
Lu, Yao
Wang, Yilong
author_facet Hu, Guoliang
Collet, Jean-Paul
Zhao, Mengxi
Lu, Yao
Wang, Yilong
author_sort Hu, Guoliang
collection PubMed
description Data linking heart rate variability (HRV) and cognitive status remains controversial and scarce, particularly in cerebral small vessel disease (CSVD) patients. Whether the association between HRV and cognitive performance exists in CSVD patients is unclear. Hence, we aimed to investigate the association between HRV and cognitive performance in patients with CSVD. This cross-sectional study was conducted among 117 CSVD patients. All patients underwent HRV assessment and global cognitive evaluation by the Mini-Mental-State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Multivariable analyses were performed to evaluate the association between HRV and cognitive status. The mean age of study population was 59.5 ± 11.8 years and 39.3% were female. After adjusting for confounding factors, a higher high frequency (HF) norm was independently associated with better MMSE scores (β = 0.051; 95% confidence interval (CI): 0.012~0.090; p = 0.011) and MoCA scores (β = 0.061; 95% CI: 0.017~0.105; p = 0.007), while a higher low frequency (LF)/HF ratio was independently associated with worse MMSE scores (β = −0.492; 95% CI: −0.893~−0.092; p = 0.017) and MoCA scores (β = −0.691; 95% CI: −1.134~−0.248; p = 0.003). The HF norm was positively associated with global cognitive performance, whereas the LF/HF ratio was negatively associated with global cognitive performance among CSVD patients. Further study of the relationship between autonomic function and cognitive performance is warranted.
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spelling pubmed-99542762023-02-25 Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease Hu, Guoliang Collet, Jean-Paul Zhao, Mengxi Lu, Yao Wang, Yilong Brain Sci Article Data linking heart rate variability (HRV) and cognitive status remains controversial and scarce, particularly in cerebral small vessel disease (CSVD) patients. Whether the association between HRV and cognitive performance exists in CSVD patients is unclear. Hence, we aimed to investigate the association between HRV and cognitive performance in patients with CSVD. This cross-sectional study was conducted among 117 CSVD patients. All patients underwent HRV assessment and global cognitive evaluation by the Mini-Mental-State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Multivariable analyses were performed to evaluate the association between HRV and cognitive status. The mean age of study population was 59.5 ± 11.8 years and 39.3% were female. After adjusting for confounding factors, a higher high frequency (HF) norm was independently associated with better MMSE scores (β = 0.051; 95% confidence interval (CI): 0.012~0.090; p = 0.011) and MoCA scores (β = 0.061; 95% CI: 0.017~0.105; p = 0.007), while a higher low frequency (LF)/HF ratio was independently associated with worse MMSE scores (β = −0.492; 95% CI: −0.893~−0.092; p = 0.017) and MoCA scores (β = −0.691; 95% CI: −1.134~−0.248; p = 0.003). The HF norm was positively associated with global cognitive performance, whereas the LF/HF ratio was negatively associated with global cognitive performance among CSVD patients. Further study of the relationship between autonomic function and cognitive performance is warranted. MDPI 2023-02-17 /pmc/articles/PMC9954276/ /pubmed/36831887 http://dx.doi.org/10.3390/brainsci13020344 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hu, Guoliang
Collet, Jean-Paul
Zhao, Mengxi
Lu, Yao
Wang, Yilong
Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title_full Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title_fullStr Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title_full_unstemmed Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title_short Associations between Autonomic Function and Cognitive Performance among Patients with Cerebral Small Vessel Disease
title_sort associations between autonomic function and cognitive performance among patients with cerebral small vessel disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954276/
https://www.ncbi.nlm.nih.gov/pubmed/36831887
http://dx.doi.org/10.3390/brainsci13020344
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