Photolithographic Fabrication of Mechanically Adaptive Devices

[Image: see text] Water-responsive polymers, which enable the design of objects whose mechanical properties or shape can be altered upon moderate swelling, are useful for a broad range of applications. However, the limited processing options of materials that exhibit useful switchable mechanical properties generally restricted their application to objects having a simple geometry. Here we show that this problem can be overcome by using a negative photoresist approach in which a linear hydrophilic polymer is converted into a highly transparent cross-linked polymer network. The photolithographic process allows the facile production of objects of complex shape and permits programming of the cross-link density, the extent of aqueous swelling, and thereby the stiffness and refractive index under physiological conditions over a wide range and with high spatial resolution. Our findings validate a straightforward route to fabricate mechanically adaptive devices for a variety of (biomedical) uses, notably optogenetic implants whose overall shape, mechanical contrast, and optical channels can all be defined by photolithography.