Cargando…
Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical prese...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954489/ https://www.ncbi.nlm.nih.gov/pubmed/36831700 http://dx.doi.org/10.3390/brainsci13020157 |
_version_ | 1784894129859198976 |
---|---|
author | De Carolis, Lanfranco Galli, Silvia Bianchini, Edoardo Rinaldi, Domiziana Raju, Manikandan Caliò, Bianca Alborghetti, Marika Pontieri, Francesco E. |
author_facet | De Carolis, Lanfranco Galli, Silvia Bianchini, Edoardo Rinaldi, Domiziana Raju, Manikandan Caliò, Bianca Alborghetti, Marika Pontieri, Francesco E. |
author_sort | De Carolis, Lanfranco |
collection | PubMed |
description | The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD. |
format | Online Article Text |
id | pubmed-9954489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99544892023-02-25 Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study De Carolis, Lanfranco Galli, Silvia Bianchini, Edoardo Rinaldi, Domiziana Raju, Manikandan Caliò, Bianca Alborghetti, Marika Pontieri, Francesco E. Brain Sci Article The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD. MDPI 2023-01-17 /pmc/articles/PMC9954489/ /pubmed/36831700 http://dx.doi.org/10.3390/brainsci13020157 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article De Carolis, Lanfranco Galli, Silvia Bianchini, Edoardo Rinaldi, Domiziana Raju, Manikandan Caliò, Bianca Alborghetti, Marika Pontieri, Francesco E. Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title_full | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title_fullStr | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title_full_unstemmed | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title_short | Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study |
title_sort | age at onset influences progression of motor and non-motor symptoms during the early stage of parkinson’s disease: a monocentric retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954489/ https://www.ncbi.nlm.nih.gov/pubmed/36831700 http://dx.doi.org/10.3390/brainsci13020157 |
work_keys_str_mv | AT decarolislanfranco ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT gallisilvia ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT bianchiniedoardo ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT rinaldidomiziana ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT rajumanikandan ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT caliobianca ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT alborghettimarika ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy AT pontierifrancescoe ageatonsetinfluencesprogressionofmotorandnonmotorsymptomsduringtheearlystageofparkinsonsdiseaseamonocentricretrospectivestudy |