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Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study

The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical prese...

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Autores principales: De Carolis, Lanfranco, Galli, Silvia, Bianchini, Edoardo, Rinaldi, Domiziana, Raju, Manikandan, Caliò, Bianca, Alborghetti, Marika, Pontieri, Francesco E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954489/
https://www.ncbi.nlm.nih.gov/pubmed/36831700
http://dx.doi.org/10.3390/brainsci13020157
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author De Carolis, Lanfranco
Galli, Silvia
Bianchini, Edoardo
Rinaldi, Domiziana
Raju, Manikandan
Caliò, Bianca
Alborghetti, Marika
Pontieri, Francesco E.
author_facet De Carolis, Lanfranco
Galli, Silvia
Bianchini, Edoardo
Rinaldi, Domiziana
Raju, Manikandan
Caliò, Bianca
Alborghetti, Marika
Pontieri, Francesco E.
author_sort De Carolis, Lanfranco
collection PubMed
description The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD.
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spelling pubmed-99544892023-02-25 Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study De Carolis, Lanfranco Galli, Silvia Bianchini, Edoardo Rinaldi, Domiziana Raju, Manikandan Caliò, Bianca Alborghetti, Marika Pontieri, Francesco E. Brain Sci Article The interactions between the age at onset with other pathogenic mechanisms and the interplays between the disease progression and the aging processes in Parkinson’s disease (PD) remain undefined, particularly during the first years of illness. Here, we retrospectively investigated the clinical presentation and evolution of the motor and non-motor symptoms and treatment-related complications during the first 5 years of illness in subjects categorized according to age at onset. A total of 131 subjects were divided into “Early-Onset-PD” (EOPD; onset ≤49 years), “Middle-Onset-PD” (MOPD; onset 50–69 years) and “Late-Onset-PD” (LOPD; onset ≥70 years). The T0 visit was set at the time of the clinical diagnosis; the T1 visit was 5 years (±5 months) later. At T0, there were no significant differences in the motor features among the groups. At T1, the LOPD patients displayed a significantly higher frequency of gait disturbances and a higher frequency of postural instability. Moreover, at T1, the LOPD subjects reported a significantly higher frequency of non-motor symptoms; in particular, cardiovascular, cognitive and neuropsychiatric domains. The presented results showed a significantly different progression of motor and non-motor symptoms in the early course of PD according to the age at onset. These findings contribute to the definition of the role of age at onset on disease progression and may be useful for the pharmacological and non-pharmacological management of PD. MDPI 2023-01-17 /pmc/articles/PMC9954489/ /pubmed/36831700 http://dx.doi.org/10.3390/brainsci13020157 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Carolis, Lanfranco
Galli, Silvia
Bianchini, Edoardo
Rinaldi, Domiziana
Raju, Manikandan
Caliò, Bianca
Alborghetti, Marika
Pontieri, Francesco E.
Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title_full Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title_fullStr Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title_full_unstemmed Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title_short Age at Onset Influences Progression of Motor and Non-Motor Symptoms during the Early Stage of Parkinson’s Disease: A Monocentric Retrospective Study
title_sort age at onset influences progression of motor and non-motor symptoms during the early stage of parkinson’s disease: a monocentric retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954489/
https://www.ncbi.nlm.nih.gov/pubmed/36831700
http://dx.doi.org/10.3390/brainsci13020157
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