Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models

SIMPLE SUMMARY: We examined the expression of SDF1α and its cognate receptor CXCR4 in human prostate cancer (PCa) lesions and the impact of CXCR4 inhibition alone and in combination with single-dose irradiation in orthotopic PCa models in mice. Both SDF1α and CXCR4 were highly expressed in primary a...

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Detalles Bibliográficos
Autores principales: Gupta, Nisha, Ochiai, Hiroki, Hoshino, Yoshinori, Klein, Sebastian, Zustin, Jozef, Ramjiawan, Rakesh R., Kitahara, Shuji, Maimon, Nir, Bazou, Despina, Chiang, Sarah, Li, Sen, Schanne, Daniel H., Jain, Rakesh. K., Munn, Lance L., Huang, Peigen, Kozin, Sergey V., Duda, Dan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954510/
https://www.ncbi.nlm.nih.gov/pubmed/36831366
http://dx.doi.org/10.3390/cancers15041021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954510/
https://www.ncbi.nlm.nih.gov/pubmed/36831366
http://dx.doi.org/10.3390/cancers15041021

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