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The Impact of Psychological Distress on Cervical Cancer

SIMPLE SUMMARY: Mood disorders including depression and bipolar were associated with an increased hazard ratio of cervical cancer. The cumulative incidence of cervical cancer was significantly higher in participants with mood disorders than in the non-mood-disorder cohort. Thus, mood disorders could...

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Autores principales: Wu, Chen-Ta, Chiu, Lu-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954541/
https://www.ncbi.nlm.nih.gov/pubmed/36831443
http://dx.doi.org/10.3390/cancers15041100
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author Wu, Chen-Ta
Chiu, Lu-Ting
author_facet Wu, Chen-Ta
Chiu, Lu-Ting
author_sort Wu, Chen-Ta
collection PubMed
description SIMPLE SUMMARY: Mood disorders including depression and bipolar were associated with an increased hazard ratio of cervical cancer. The cumulative incidence of cervical cancer was significantly higher in participants with mood disorders than in the non-mood-disorder cohort. Thus, mood disorders could potentially increase the risk of developing subsequent cervical cancer. ABSTRACT: Objective: Psychological distress is considered a factor for cancer development. However, the impact of mood disorders (depression and bipolar) on the development of cervical cancer remains uncertain. We conducted a nationwide population-based retrospective cohort study to investigate the association between mood disorders and the subsequent risk of developing cervical cancer. Methods: A total of 138,130 participants’ profiles between 2000 and 2012 were extracted from the National Health Insurance Research Database and subdivided into a mood-disorder cohort (27,626 participants) and a non-mood-disorder cohort (110,504 participants). Cohorts were propensity-matched for a 1:4 ratio according to age and index year. The Cox proportional hazards regression model was utilized for assessing cervical cancer risk between cohorts. Results: Kaplan–Meier analysis revealed that the mood-disorder cohort had a higher cumulative incidence of cervical cancer. The mood-disorder cohort was also associated with an increased risk of cervical cancer after adjustments for potential confounders. Subgroup analysis revealed a negative impact of mood disorders on cervical cancer, especially in the 30–50 years and white-collar groups. Conclusions: Our findings demonstrated that mood disorders were associated with an increased risk of cervical cancer development, which provide helpful information for clinical strategies to reduce the incidence of cervical cancer in this vulnerable population.
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spelling pubmed-99545412023-02-25 The Impact of Psychological Distress on Cervical Cancer Wu, Chen-Ta Chiu, Lu-Ting Cancers (Basel) Article SIMPLE SUMMARY: Mood disorders including depression and bipolar were associated with an increased hazard ratio of cervical cancer. The cumulative incidence of cervical cancer was significantly higher in participants with mood disorders than in the non-mood-disorder cohort. Thus, mood disorders could potentially increase the risk of developing subsequent cervical cancer. ABSTRACT: Objective: Psychological distress is considered a factor for cancer development. However, the impact of mood disorders (depression and bipolar) on the development of cervical cancer remains uncertain. We conducted a nationwide population-based retrospective cohort study to investigate the association between mood disorders and the subsequent risk of developing cervical cancer. Methods: A total of 138,130 participants’ profiles between 2000 and 2012 were extracted from the National Health Insurance Research Database and subdivided into a mood-disorder cohort (27,626 participants) and a non-mood-disorder cohort (110,504 participants). Cohorts were propensity-matched for a 1:4 ratio according to age and index year. The Cox proportional hazards regression model was utilized for assessing cervical cancer risk between cohorts. Results: Kaplan–Meier analysis revealed that the mood-disorder cohort had a higher cumulative incidence of cervical cancer. The mood-disorder cohort was also associated with an increased risk of cervical cancer after adjustments for potential confounders. Subgroup analysis revealed a negative impact of mood disorders on cervical cancer, especially in the 30–50 years and white-collar groups. Conclusions: Our findings demonstrated that mood disorders were associated with an increased risk of cervical cancer development, which provide helpful information for clinical strategies to reduce the incidence of cervical cancer in this vulnerable population. MDPI 2023-02-09 /pmc/articles/PMC9954541/ /pubmed/36831443 http://dx.doi.org/10.3390/cancers15041100 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Chen-Ta
Chiu, Lu-Ting
The Impact of Psychological Distress on Cervical Cancer
title The Impact of Psychological Distress on Cervical Cancer
title_full The Impact of Psychological Distress on Cervical Cancer
title_fullStr The Impact of Psychological Distress on Cervical Cancer
title_full_unstemmed The Impact of Psychological Distress on Cervical Cancer
title_short The Impact of Psychological Distress on Cervical Cancer
title_sort impact of psychological distress on cervical cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954541/
https://www.ncbi.nlm.nih.gov/pubmed/36831443
http://dx.doi.org/10.3390/cancers15041100
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