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Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases

Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of inflammation, cellular development, and differentiati...

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Autores principales: Kim, In Soo, Silwal, Prashanta, Jo, Eun-Kyeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954612/
https://www.ncbi.nlm.nih.gov/pubmed/36831317
http://dx.doi.org/10.3390/cells12040650
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author Kim, In Soo
Silwal, Prashanta
Jo, Eun-Kyeong
author_facet Kim, In Soo
Silwal, Prashanta
Jo, Eun-Kyeong
author_sort Kim, In Soo
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of inflammation, cellular development, and differentiation. The many roles played by the PPAR signaling pathways indicate that PPARs may be useful targets for various human diseases, including metabolic and inflammatory conditions and tumors. Accumulating evidence suggests that each PPAR plays prominent but different roles in viral, bacterial, and parasitic infectious disease development. In this review, we discuss recent PPAR research works that are focused on how PPARs control various infections and immune responses. In addition, we describe the current and potential therapeutic uses of PPAR agonists/antagonists in the context of infectious diseases. A more comprehensive understanding of the roles played by PPARs in terms of host-pathogen interactions will yield potential adjunctive personalized therapies employing PPAR-modulating agents.
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spelling pubmed-99546122023-02-25 Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases Kim, In Soo Silwal, Prashanta Jo, Eun-Kyeong Cells Review Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are nuclear receptors that orchestrate the transcriptional regulation of genes involved in a variety of biological responses, such as energy metabolism and homeostasis, regulation of inflammation, cellular development, and differentiation. The many roles played by the PPAR signaling pathways indicate that PPARs may be useful targets for various human diseases, including metabolic and inflammatory conditions and tumors. Accumulating evidence suggests that each PPAR plays prominent but different roles in viral, bacterial, and parasitic infectious disease development. In this review, we discuss recent PPAR research works that are focused on how PPARs control various infections and immune responses. In addition, we describe the current and potential therapeutic uses of PPAR agonists/antagonists in the context of infectious diseases. A more comprehensive understanding of the roles played by PPARs in terms of host-pathogen interactions will yield potential adjunctive personalized therapies employing PPAR-modulating agents. MDPI 2023-02-17 /pmc/articles/PMC9954612/ /pubmed/36831317 http://dx.doi.org/10.3390/cells12040650 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, In Soo
Silwal, Prashanta
Jo, Eun-Kyeong
Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title_full Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title_fullStr Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title_full_unstemmed Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title_short Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases
title_sort peroxisome proliferator-activated receptor-targeted therapies: challenges upon infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954612/
https://www.ncbi.nlm.nih.gov/pubmed/36831317
http://dx.doi.org/10.3390/cells12040650
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