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Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective
Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators;...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954655/ https://www.ncbi.nlm.nih.gov/pubmed/36831786 http://dx.doi.org/10.3390/brainsci13020243 |
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author | Ebada, Mahmoud A. Mostafa, Abdalrhman Gadallah, Al-Hussein A. Alkanj, Souad Alghamdi, Badrah S. Ashraf, Ghulam Md Abuzenadah, Adel M. Alserihi, Raed F. Wadaa-Allah, Ahmed Salama, Mohamed |
author_facet | Ebada, Mahmoud A. Mostafa, Abdalrhman Gadallah, Al-Hussein A. Alkanj, Souad Alghamdi, Badrah S. Ashraf, Ghulam Md Abuzenadah, Adel M. Alserihi, Raed F. Wadaa-Allah, Ahmed Salama, Mohamed |
author_sort | Ebada, Mahmoud A. |
collection | PubMed |
description | Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders. |
format | Online Article Text |
id | pubmed-9954655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99546552023-02-25 Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective Ebada, Mahmoud A. Mostafa, Abdalrhman Gadallah, Al-Hussein A. Alkanj, Souad Alghamdi, Badrah S. Ashraf, Ghulam Md Abuzenadah, Adel M. Alserihi, Raed F. Wadaa-Allah, Ahmed Salama, Mohamed Brain Sci Review Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders. MDPI 2023-01-31 /pmc/articles/PMC9954655/ /pubmed/36831786 http://dx.doi.org/10.3390/brainsci13020243 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ebada, Mahmoud A. Mostafa, Abdalrhman Gadallah, Al-Hussein A. Alkanj, Souad Alghamdi, Badrah S. Ashraf, Ghulam Md Abuzenadah, Adel M. Alserihi, Raed F. Wadaa-Allah, Ahmed Salama, Mohamed Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title | Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title_full | Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title_fullStr | Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title_full_unstemmed | Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title_short | Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective |
title_sort | potential regulation of mirna-29 and mirna-9 by estrogens in neurodegenerative disorders: an insightful perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954655/ https://www.ncbi.nlm.nih.gov/pubmed/36831786 http://dx.doi.org/10.3390/brainsci13020243 |
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