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SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation

The p38 inhibitor SB202190 is a necessary component of the medium used for normal colorectal mucosa cultures. Sato et al. suggested that the primary activity of SB202190 may be EGFR signaling stabilization, causing an increased phosphorylation of Erk1-2 sustaining organoid proliferation. However, th...

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Detalles Bibliográficos
Autores principales:	Costa, Delfina, Venè, Roberta, Coco, Simona, Longo, Luca, Tosetti, Francesca, Scabini, Stefano, Mastracci, Luca, Grillo, Federica, Poggi, Alessandro, Benelli, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954675/ https://www.ncbi.nlm.nih.gov/pubmed/36831331 http://dx.doi.org/10.3390/cells12040664

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