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Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging

Background: While type 2 diabetes (T2D) is a major risk for ischemic stroke, the associated vessel wall characteristics remain essentially unknown. This study aimed to clarify intracranial vascular changes on three-dimensional vessel wall imaging (3D-VWI) using fast spin echo by employing 7Tesla (7T...

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Autores principales: Shozushima, Masaharu, Mori, Futoshi, Yashiro, Satoshi, Todate, Yusuke, Oda, Tomoyasu, Nagasawa, Kan, Hasegawa, Yutaka, Takebe, Noriko, Sasaki, Makoto, Ishigaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954742/
https://www.ncbi.nlm.nih.gov/pubmed/36831760
http://dx.doi.org/10.3390/brainsci13020217
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author Shozushima, Masaharu
Mori, Futoshi
Yashiro, Satoshi
Todate, Yusuke
Oda, Tomoyasu
Nagasawa, Kan
Hasegawa, Yutaka
Takebe, Noriko
Sasaki, Makoto
Ishigaki, Yasushi
author_facet Shozushima, Masaharu
Mori, Futoshi
Yashiro, Satoshi
Todate, Yusuke
Oda, Tomoyasu
Nagasawa, Kan
Hasegawa, Yutaka
Takebe, Noriko
Sasaki, Makoto
Ishigaki, Yasushi
author_sort Shozushima, Masaharu
collection PubMed
description Background: While type 2 diabetes (T2D) is a major risk for ischemic stroke, the associated vessel wall characteristics remain essentially unknown. This study aimed to clarify intracranial vascular changes on three-dimensional vessel wall imaging (3D-VWI) using fast spin echo by employing 7Tesla (7T) magnetic resonance imaging (MRI) in T2D patients without advanced atherosclerosis as compared to healthy controls. Methods: In 48 T2D patients and 35 healthy controls, the prevalence of cerebral small vessel diseases and intracranial plaques were evaluated by 3D-VWI with 7T MRI. Results: The prevalence rate of lacunar infarction was significantly higher in T2D than in controls (n = 8 in T2D vs. n = 0 in control, p = 0.011). The mean number of intracranial plaques in both anterior and posterior circulation of each subject was significantly larger in T2D than in controls (2.23 in T2D vs. 0.94 in control, p < 0.01). In T2D patients, gender was associated with the presence of intracranial plaques. Conclusion: This is the first study to demonstrate the high prevalence of intracranial plaque in T2D patients with neither confirmed atherosclerotic disease nor symptoms by performing intracranial 3D-VWI employing 7TMRI. Investigation of intracranial VWI with 7T MRI is expected to provide novel insights allowing early intensive risk management for prevention of ischemic stroke in T2D patients.
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spelling pubmed-99547422023-02-25 Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging Shozushima, Masaharu Mori, Futoshi Yashiro, Satoshi Todate, Yusuke Oda, Tomoyasu Nagasawa, Kan Hasegawa, Yutaka Takebe, Noriko Sasaki, Makoto Ishigaki, Yasushi Brain Sci Article Background: While type 2 diabetes (T2D) is a major risk for ischemic stroke, the associated vessel wall characteristics remain essentially unknown. This study aimed to clarify intracranial vascular changes on three-dimensional vessel wall imaging (3D-VWI) using fast spin echo by employing 7Tesla (7T) magnetic resonance imaging (MRI) in T2D patients without advanced atherosclerosis as compared to healthy controls. Methods: In 48 T2D patients and 35 healthy controls, the prevalence of cerebral small vessel diseases and intracranial plaques were evaluated by 3D-VWI with 7T MRI. Results: The prevalence rate of lacunar infarction was significantly higher in T2D than in controls (n = 8 in T2D vs. n = 0 in control, p = 0.011). The mean number of intracranial plaques in both anterior and posterior circulation of each subject was significantly larger in T2D than in controls (2.23 in T2D vs. 0.94 in control, p < 0.01). In T2D patients, gender was associated with the presence of intracranial plaques. Conclusion: This is the first study to demonstrate the high prevalence of intracranial plaque in T2D patients with neither confirmed atherosclerotic disease nor symptoms by performing intracranial 3D-VWI employing 7TMRI. Investigation of intracranial VWI with 7T MRI is expected to provide novel insights allowing early intensive risk management for prevention of ischemic stroke in T2D patients. MDPI 2023-01-28 /pmc/articles/PMC9954742/ /pubmed/36831760 http://dx.doi.org/10.3390/brainsci13020217 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shozushima, Masaharu
Mori, Futoshi
Yashiro, Satoshi
Todate, Yusuke
Oda, Tomoyasu
Nagasawa, Kan
Hasegawa, Yutaka
Takebe, Noriko
Sasaki, Makoto
Ishigaki, Yasushi
Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title_full Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title_fullStr Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title_full_unstemmed Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title_short Evaluation of High Intracranial Plaque Prevalence in Type 2 Diabetes Using Vessel Wall Imaging on 7 T Magnetic Resonance Imaging
title_sort evaluation of high intracranial plaque prevalence in type 2 diabetes using vessel wall imaging on 7 t magnetic resonance imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954742/
https://www.ncbi.nlm.nih.gov/pubmed/36831760
http://dx.doi.org/10.3390/brainsci13020217
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