Prognosis of Pancreatic Cancer Based on Resectability: A Single Center Experience

SIMPLE SUMMARY: Conversion surgery has been increasingly performed for initially unresectable advanced pancreatic ductal adenocarcinoma (PDAC). Patients with PDAC were classified into three groups: resectable (R), borderline resectable (BR), and unresectable (UR). In total, 211 patients (R, 118; BR,...

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Detalles Bibliográficos
Autores principales: Einama, Takahiro, Takihata, Yasuhiro, Aosasa, Suefumi, Konno, Fukumi, Kobayashi, Kazuki, Yonamine, Naoto, Fujinuma, Ibuki, Tsunenari, Takazumi, Nakazawa, Akiko, Shinto, Eiji, Ueno, Hideki, Kishi, Yoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954753/
https://www.ncbi.nlm.nih.gov/pubmed/36831444
http://dx.doi.org/10.3390/cancers15041101
Descripción
Sumario:SIMPLE SUMMARY: Conversion surgery has been increasingly performed for initially unresectable advanced pancreatic ductal adenocarcinoma (PDAC). Patients with PDAC were classified into three groups: resectable (R), borderline resectable (BR), and unresectable (UR). In total, 211 patients (R, 118; BR, 22; UR, 81) were selected. Among them, 117 (99%), 18 (82%), and 15 (19%) patients in the R, BR, and UR groups underwent surgical resection. R0 resection rates were 88%, 78%, and 67%, whereas median overall survival (OS) rates from treatment initiation were 31, 18, and 11 months (p < 0.0001) in the R, BR, and UR groups, respectively. In patients who underwent surgical resection, relapse-free survival (RFS) and OS were similar. Lymph node metastases and incomplete adjuvant chemotherapy were identified as independent prognostic factors for OS. ABSTRACT: Although conversion surgery has increasingly been performed for initially unresectable advanced pancreatic ductal adenocarcinoma (PDAC), the rate of conversion, including that for patients who do not undergo resection, remains unclear. Patients with PDAC who were treated between January 2013 and December 2018 were classified into three groups: resectable (R), borderline resectable (BR), and unresectable (UR). We analyzed patient outcomes, including the rate of surgical resection and survival, in each of these groups. In total, 211 patients (R, 118; BR, 22; UR, 81) were selected. Among them, 117 (99%), 18 (82%), and 15 (19%) patients in the R, BR, and UR groups, respectively, underwent surgical resection. R0 resection rates were 88, 78, and 67%, whereas median overall survival (OS) from treatment initiation were 31, 18, and 11 months (p < 0.0001) in the R, BR, and UR groups, respectively. In patients who underwent surgical resection, relapse-free survival (RFS) and OS were similar among the three groups (R vs. BR vs. UR; median RFS (months), 17 vs. 13 vs. 11, p = 0.249; median OS (months), 31 vs. 26 vs. 32, p = 0.742). Lymph node metastases and incomplete adjuvant chemotherapy were identified as independent prognostic factors for OS. Although the surgical resection rate was low, particularly in the BR and UR groups, the prognosis of patients who underwent surgical resection was similar irrespective of the initial resectability status.

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