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Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study

Members of the activator protein 2 (AP-2) transcription factor (TF) family are known to play a role in both physiological processes and cancer development. The family comprises five DNA-binding proteins encoded by the TFAP2A to TFAP2E genes. Numerous scientific reports describe differential expressi...

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Autores principales: Szmajda-Krygier, Dagmara, Krygier, Adrian, Żebrowska-Nawrocka, Marta, Pietrzak, Jacek, Świechowski, Rafał, Wosiak, Agnieszka, Jeleń, Agnieszka, Balcerczak, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954805/
https://www.ncbi.nlm.nih.gov/pubmed/36831334
http://dx.doi.org/10.3390/cells12040667
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author Szmajda-Krygier, Dagmara
Krygier, Adrian
Żebrowska-Nawrocka, Marta
Pietrzak, Jacek
Świechowski, Rafał
Wosiak, Agnieszka
Jeleń, Agnieszka
Balcerczak, Ewa
author_facet Szmajda-Krygier, Dagmara
Krygier, Adrian
Żebrowska-Nawrocka, Marta
Pietrzak, Jacek
Świechowski, Rafał
Wosiak, Agnieszka
Jeleń, Agnieszka
Balcerczak, Ewa
author_sort Szmajda-Krygier, Dagmara
collection PubMed
description Members of the activator protein 2 (AP-2) transcription factor (TF) family are known to play a role in both physiological processes and cancer development. The family comprises five DNA-binding proteins encoded by the TFAP2A to TFAP2E genes. Numerous scientific reports describe differential expression of these TF and their genes in various types of cancer, identifying among them a potential oncogene or suppressor like TFAP2A or TFAP2C. Other reports suggest their influence on disease development and progression, as well as response to treatment. Not all members of this AP-2 family have been comprehensively studied thus far. The aim of the present article is to gather and discuss knowledge available in bioinformatics databases regarding all five members of this family and to differentiate them in relation to the two most common lung cancer subtypes: adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). In addition, to assess the difference in levels depending on a number of clinicopathological factors, the impact on patient survival and interactions with tumor-infiltrating immune cells. This article may help to identify the target for further original research that may contribute to the discovery of new diagnostic biomarkers and define the molecular differences between LUAD and LUSC, which may affect the therapy effectiveness improvement and longer survival.
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spelling pubmed-99548052023-02-25 Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study Szmajda-Krygier, Dagmara Krygier, Adrian Żebrowska-Nawrocka, Marta Pietrzak, Jacek Świechowski, Rafał Wosiak, Agnieszka Jeleń, Agnieszka Balcerczak, Ewa Cells Article Members of the activator protein 2 (AP-2) transcription factor (TF) family are known to play a role in both physiological processes and cancer development. The family comprises five DNA-binding proteins encoded by the TFAP2A to TFAP2E genes. Numerous scientific reports describe differential expression of these TF and their genes in various types of cancer, identifying among them a potential oncogene or suppressor like TFAP2A or TFAP2C. Other reports suggest their influence on disease development and progression, as well as response to treatment. Not all members of this AP-2 family have been comprehensively studied thus far. The aim of the present article is to gather and discuss knowledge available in bioinformatics databases regarding all five members of this family and to differentiate them in relation to the two most common lung cancer subtypes: adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). In addition, to assess the difference in levels depending on a number of clinicopathological factors, the impact on patient survival and interactions with tumor-infiltrating immune cells. This article may help to identify the target for further original research that may contribute to the discovery of new diagnostic biomarkers and define the molecular differences between LUAD and LUSC, which may affect the therapy effectiveness improvement and longer survival. MDPI 2023-02-20 /pmc/articles/PMC9954805/ /pubmed/36831334 http://dx.doi.org/10.3390/cells12040667 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szmajda-Krygier, Dagmara
Krygier, Adrian
Żebrowska-Nawrocka, Marta
Pietrzak, Jacek
Świechowski, Rafał
Wosiak, Agnieszka
Jeleń, Agnieszka
Balcerczak, Ewa
Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title_full Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title_fullStr Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title_full_unstemmed Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title_short Differential Expression of AP-2 Transcription Factors Family in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma—A Bioinformatics Study
title_sort differential expression of ap-2 transcription factors family in lung adenocarcinoma and lung squamous cell carcinoma—a bioinformatics study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954805/
https://www.ncbi.nlm.nih.gov/pubmed/36831334
http://dx.doi.org/10.3390/cells12040667
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