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Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology

Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is generally indolent, however, could advance to invasive carcinoma in more than one-third of cases if left untreated. Thus, there is continuous research to find DCIS characteristics that would enable clinicians to decide i...

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Autores principales: Łazarczyk, Agnieszka, Streb, Joanna, Hałubiec, Przemysław, Streb-Smoleń, Anna, Jach, Robert, Hodorowicz-Zaniewska, Diana, Łuczyńska, Elżbieta, Szpor, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954835/
https://www.ncbi.nlm.nih.gov/pubmed/36832275
http://dx.doi.org/10.3390/diagnostics13040787
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author Łazarczyk, Agnieszka
Streb, Joanna
Hałubiec, Przemysław
Streb-Smoleń, Anna
Jach, Robert
Hodorowicz-Zaniewska, Diana
Łuczyńska, Elżbieta
Szpor, Joanna
author_facet Łazarczyk, Agnieszka
Streb, Joanna
Hałubiec, Przemysław
Streb-Smoleń, Anna
Jach, Robert
Hodorowicz-Zaniewska, Diana
Łuczyńska, Elżbieta
Szpor, Joanna
author_sort Łazarczyk, Agnieszka
collection PubMed
description Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is generally indolent, however, could advance to invasive carcinoma in more than one-third of cases if left untreated. Thus, there is continuous research to find DCIS characteristics that would enable clinicians to decide if it could be left without intensive treatment. Neoductgenesis (i.e., formation of the new duct of improper morphology) is a promising, but still not sufficiently evaluated indicator of future tumor invasiveness. We gathered data from 96 cases of DCIS (histopathological, clinical, and radiological) to assess the relationship between the neoductgenesis and well-established features of high-risk tumor behavior. Furthermore, our intention was to determine which degree of neoductgenesis should be considered clinically significant. Our major finding was that neoductgenesis is strictly related to other characteristics that indicate the invasive potential of the tumor and, to achieve more accurate prediction, neoductgenesis should be accordingly recognized to less strict criteria. Therefore, we conclude that neoductgenesis is another important revelator of tumor malignancy and that it requires further investigation during prospective controlled trials.
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spelling pubmed-99548352023-02-25 Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology Łazarczyk, Agnieszka Streb, Joanna Hałubiec, Przemysław Streb-Smoleń, Anna Jach, Robert Hodorowicz-Zaniewska, Diana Łuczyńska, Elżbieta Szpor, Joanna Diagnostics (Basel) Article Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer that is generally indolent, however, could advance to invasive carcinoma in more than one-third of cases if left untreated. Thus, there is continuous research to find DCIS characteristics that would enable clinicians to decide if it could be left without intensive treatment. Neoductgenesis (i.e., formation of the new duct of improper morphology) is a promising, but still not sufficiently evaluated indicator of future tumor invasiveness. We gathered data from 96 cases of DCIS (histopathological, clinical, and radiological) to assess the relationship between the neoductgenesis and well-established features of high-risk tumor behavior. Furthermore, our intention was to determine which degree of neoductgenesis should be considered clinically significant. Our major finding was that neoductgenesis is strictly related to other characteristics that indicate the invasive potential of the tumor and, to achieve more accurate prediction, neoductgenesis should be accordingly recognized to less strict criteria. Therefore, we conclude that neoductgenesis is another important revelator of tumor malignancy and that it requires further investigation during prospective controlled trials. MDPI 2023-02-19 /pmc/articles/PMC9954835/ /pubmed/36832275 http://dx.doi.org/10.3390/diagnostics13040787 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Łazarczyk, Agnieszka
Streb, Joanna
Hałubiec, Przemysław
Streb-Smoleń, Anna
Jach, Robert
Hodorowicz-Zaniewska, Diana
Łuczyńska, Elżbieta
Szpor, Joanna
Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title_full Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title_fullStr Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title_full_unstemmed Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title_short Neoductgenesis in Ductal Carcinoma In Situ Coexists with Morphological Abnormalities Characteristic for More Aggressive Tumor Biology
title_sort neoductgenesis in ductal carcinoma in situ coexists with morphological abnormalities characteristic for more aggressive tumor biology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954835/
https://www.ncbi.nlm.nih.gov/pubmed/36832275
http://dx.doi.org/10.3390/diagnostics13040787
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