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Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States

Renal transplantation is the treatment of choice for patients suffering from chronic renal disease, one of the leading causes of death worldwide. Among the biological barriers that may increase the risk of acute renal graft rejection is the presence of human leukocyte antigen (HLA) incompatibilities...

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Autores principales: Talaminos Barroso, Alejandro, Reina Tosina, Javier, Roa, Laura M., Calvillo Arbizu, Jorge, Pérez Valdivia, Miguel Angel, Medina, Rafael, Rocha Castilla, Jose Luis, Castro-de-la-Nuez, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954912/
https://www.ncbi.nlm.nih.gov/pubmed/36832096
http://dx.doi.org/10.3390/diagnostics13040608
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author Talaminos Barroso, Alejandro
Reina Tosina, Javier
Roa, Laura M.
Calvillo Arbizu, Jorge
Pérez Valdivia, Miguel Angel
Medina, Rafael
Rocha Castilla, Jose Luis
Castro-de-la-Nuez, Pablo
author_facet Talaminos Barroso, Alejandro
Reina Tosina, Javier
Roa, Laura M.
Calvillo Arbizu, Jorge
Pérez Valdivia, Miguel Angel
Medina, Rafael
Rocha Castilla, Jose Luis
Castro-de-la-Nuez, Pablo
author_sort Talaminos Barroso, Alejandro
collection PubMed
description Renal transplantation is the treatment of choice for patients suffering from chronic renal disease, one of the leading causes of death worldwide. Among the biological barriers that may increase the risk of acute renal graft rejection is the presence of human leukocyte antigen (HLA) incompatibilities between donor and recipient. This work presents a comparative study of the influence of HLA incompatibilities on renal transplantation survival in the Andalusian (South of Spain) and United States (US) population. The main objective is to analyse the extent to which results about the influence of different factors on renal graft survival can be generalised to different populations. The Kaplan–Meier estimator and the Cox model have been used to identify and quantify the impact on the survival probability of HLA incompatibilities, both in isolation and in conjunction with other factors associated with the donor and recipient. According to the results obtained, HLA incompatibilities considered in isolation have negligible impact on renal survival in the Andalusian population and a moderate impact in the US population. Grouping by HLA score presents some similarities for both populations, while the sum of all HLA scores (aHLA) only has an impact on the US population. Finally, the graft survival probability of the two populations differs when aHLA is considered in conjunction with blood type. The results suggest that the disparities in the renal graft survival probability between the two populations under study are due not only to biological and transplantation-associated factors, but also to social–health factors and ethnic heterogeneity between populations.
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spelling pubmed-99549122023-02-25 Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States Talaminos Barroso, Alejandro Reina Tosina, Javier Roa, Laura M. Calvillo Arbizu, Jorge Pérez Valdivia, Miguel Angel Medina, Rafael Rocha Castilla, Jose Luis Castro-de-la-Nuez, Pablo Diagnostics (Basel) Article Renal transplantation is the treatment of choice for patients suffering from chronic renal disease, one of the leading causes of death worldwide. Among the biological barriers that may increase the risk of acute renal graft rejection is the presence of human leukocyte antigen (HLA) incompatibilities between donor and recipient. This work presents a comparative study of the influence of HLA incompatibilities on renal transplantation survival in the Andalusian (South of Spain) and United States (US) population. The main objective is to analyse the extent to which results about the influence of different factors on renal graft survival can be generalised to different populations. The Kaplan–Meier estimator and the Cox model have been used to identify and quantify the impact on the survival probability of HLA incompatibilities, both in isolation and in conjunction with other factors associated with the donor and recipient. According to the results obtained, HLA incompatibilities considered in isolation have negligible impact on renal survival in the Andalusian population and a moderate impact in the US population. Grouping by HLA score presents some similarities for both populations, while the sum of all HLA scores (aHLA) only has an impact on the US population. Finally, the graft survival probability of the two populations differs when aHLA is considered in conjunction with blood type. The results suggest that the disparities in the renal graft survival probability between the two populations under study are due not only to biological and transplantation-associated factors, but also to social–health factors and ethnic heterogeneity between populations. MDPI 2023-02-07 /pmc/articles/PMC9954912/ /pubmed/36832096 http://dx.doi.org/10.3390/diagnostics13040608 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Talaminos Barroso, Alejandro
Reina Tosina, Javier
Roa, Laura M.
Calvillo Arbizu, Jorge
Pérez Valdivia, Miguel Angel
Medina, Rafael
Rocha Castilla, Jose Luis
Castro-de-la-Nuez, Pablo
Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title_full Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title_fullStr Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title_full_unstemmed Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title_short Comparative Study of the Impact of Human Leukocyte Antigens on Renal Transplant Survival in Andalusia and the United States
title_sort comparative study of the impact of human leukocyte antigens on renal transplant survival in andalusia and the united states
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954912/
https://www.ncbi.nlm.nih.gov/pubmed/36832096
http://dx.doi.org/10.3390/diagnostics13040608
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