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Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954945/ https://www.ncbi.nlm.nih.gov/pubmed/36832376 http://dx.doi.org/10.3390/children10020248 |
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author | Geronikolou, Styliani A. Vasdekis, Vasilis Mantzou, Aimilia Davos, Constantinos Cokkinos, Dennis V. Chrousos, George P. |
author_facet | Geronikolou, Styliani A. Vasdekis, Vasilis Mantzou, Aimilia Davos, Constantinos Cokkinos, Dennis V. Chrousos, George P. |
author_sort | Geronikolou, Styliani A. |
collection | PubMed |
description | This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11–14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1–4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli. |
format | Online Article Text |
id | pubmed-9954945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99549452023-02-25 Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study Geronikolou, Styliani A. Vasdekis, Vasilis Mantzou, Aimilia Davos, Constantinos Cokkinos, Dennis V. Chrousos, George P. Children (Basel) Article This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11–14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1–4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli. MDPI 2023-01-30 /pmc/articles/PMC9954945/ /pubmed/36832376 http://dx.doi.org/10.3390/children10020248 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Geronikolou, Styliani A. Vasdekis, Vasilis Mantzou, Aimilia Davos, Constantinos Cokkinos, Dennis V. Chrousos, George P. Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title | Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title_full | Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title_fullStr | Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title_full_unstemmed | Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title_short | Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study |
title_sort | neuroendocrine system adaptation during consecutive extrinsic stimuli: a pilot dynamic study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954945/ https://www.ncbi.nlm.nih.gov/pubmed/36832376 http://dx.doi.org/10.3390/children10020248 |
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