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Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study

This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and...

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Autores principales: Geronikolou, Styliani A., Vasdekis, Vasilis, Mantzou, Aimilia, Davos, Constantinos, Cokkinos, Dennis V., Chrousos, George P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954945/
https://www.ncbi.nlm.nih.gov/pubmed/36832376
http://dx.doi.org/10.3390/children10020248
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author Geronikolou, Styliani A.
Vasdekis, Vasilis
Mantzou, Aimilia
Davos, Constantinos
Cokkinos, Dennis V.
Chrousos, George P.
author_facet Geronikolou, Styliani A.
Vasdekis, Vasilis
Mantzou, Aimilia
Davos, Constantinos
Cokkinos, Dennis V.
Chrousos, George P.
author_sort Geronikolou, Styliani A.
collection PubMed
description This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11–14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1–4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli.
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spelling pubmed-99549452023-02-25 Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study Geronikolou, Styliani A. Vasdekis, Vasilis Mantzou, Aimilia Davos, Constantinos Cokkinos, Dennis V. Chrousos, George P. Children (Basel) Article This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic–pituitary–adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11–14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1–4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli. MDPI 2023-01-30 /pmc/articles/PMC9954945/ /pubmed/36832376 http://dx.doi.org/10.3390/children10020248 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Geronikolou, Styliani A.
Vasdekis, Vasilis
Mantzou, Aimilia
Davos, Constantinos
Cokkinos, Dennis V.
Chrousos, George P.
Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title_full Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title_fullStr Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title_full_unstemmed Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title_short Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study
title_sort neuroendocrine system adaptation during consecutive extrinsic stimuli: a pilot dynamic study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954945/
https://www.ncbi.nlm.nih.gov/pubmed/36832376
http://dx.doi.org/10.3390/children10020248
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