Cargando…

Chemopreventive Effects of Onosma mutabilis against Azoxymethane-Induced Colon Cancer in Rats via Amendment of Bax/Bcl-2 and NF-κB Signaling Pathways

Onosma species (Boraginaceae) are well known as medicinal plants due to their wide range of pharmaceutical potential. The present study aims to investigate the anticancer (in vitro) and chemo-protective (in vivo) efficacies of Onosma mutabilis extract (OME) in the azoxymethane (AOM)-induced aberrant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jabbar, Ahmed Aj., Ibrahim, Ibrahim Abdel Aziz, Abdullah, Fuad O., Aziz, Kareem Fattah, Alzahrani, Abdullah R., Abdulla, Mahmood Ameen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954954/ https://www.ncbi.nlm.nih.gov/pubmed/36826002 http://dx.doi.org/10.3390/cimb45020057

Ejemplares similares

Onosma mutabilis: Phytochemical composition, antioxidant, cytotoxicity, and acute oral toxicity
por: Jabbar, Ahmed Aj.
Publicado: (2021)

Ethnobotanical, Phytochemistry, and Pharmacological Activity of Onosma (Boraginaceae): An Updated Review
por: Jabbar, Ahmed Aj., et al.
Publicado: (2022)

Subcritical Water Extraction of Onosma mutabilis: Process Optimization and Chemical Profile of the Extracts
por: Çalhan, Selda Doğan, et al.
Publicado: (2023)

Chemopreventive Efficacy of Andrographis paniculata on Azoxymethane-Induced Aberrant Colon Crypt Foci In Vivo
por: Al-Henhena, Nawal, et al.
Publicado: (2014)

The chemopreventive potential of Curcuma purpurascens rhizome in reducing azoxymethane-induced aberrant crypt foci in rats
por: Rouhollahi, Elham, et al.
Publicado: (2015)

Chemopreventive Evaluation of a Schiff Base Derived Copper (II) Complex against Azoxymethane-Induced Colorectal Cancer in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2014)

Chemopreventive effects of Strobilanthes crispus leaf extract on azoxymethane-induced aberrant crypt foci in rat colon
por: Al-Henhena, Nawal, et al.
Publicado: (2015)

Evaluation of Chemopreventive Effects of Acanthus ilicifolius against Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon
por: Almagrami, Amel A., et al.
Publicado: (2014)

Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane
por: Saiful Yazan, Latifah, et al.
Publicado: (2016)

Hepatoprotective effects of methanolic extract of green tea against Thioacetamide-Induced liver injury in Sprague Dawley rats
por: Hamad Shareef, Suhayla, et al.
Publicado: (2022)

Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer
por: Guo, Yangyang, et al.
Publicado: (2020)

Correction: Chemopreventive Efficacy of Andrographis paniculata on Azoxymethane-Induced Aberrant Colon Crypt Foci In Vivo
Publicado: (2015)

Regressive Effects of Various Chemopreventive Agents on Azoxymethane‐induced Aberrant Crypt Foci in the Rat Colon
por: Morishita, Yukio, et al.
Publicado: (1997)

Correction to: Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer
por: Guo, Yangyang, et al.
Publicado: (2021)

Onosma hispidum L. extract reverses hyperlipidemia, hypertension, and associated vascular dysfunction in rats
por: Ullah Wazir, Nadeem, et al.
Publicado: (2023)

Chemoprevention of Azoxymethane‐induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1′‐Acetoxychavicol Acetate
por: Tanaka, Takuji, et al.
Publicado: (1997)

Onosma L.: A review of phytochemistry and ethnopharmacology
por: Kumar, Neeraj, et al.
Publicado: (2013)

Chemical Composition, Antioxidant and Enzyme Inhibitory Activities of Onosma bourgaei and Onosma trachytricha and in Silico Molecular Docking Analysis of Dominant Compounds
por: Istifli, Erman Salih
Publicado: (2021)

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
por: Kulsoom, Bibi, et al.
Publicado: (2018)

Chemoprevention of Colonic Aberrant Crypt Foci by Novel Schiff Based Dichlorido(4-Methoxy-2-{[2-(Piperazin-4-Ium-1-Yl)Ethyl]Iminomethyl}Phenolate)Cd Complex in Azoxymethane-Induced Colorectal Cancer in Rats
por: Hajrezaie, Maryam, et al.
Publicado: (2015)

Mechanisms of anti-ulcer actions of Prangos pabularia (L.) in ethanol-induced gastric ulcer in rats
por: Jabbar, Ahmed A.J., et al.
Publicado: (2023)

The Action of Bax and Bcl-2 on T Cell Selection
por: Williams, Owen, et al.
Publicado: (1998)

Chemopreventive Potential of Synergy1 and Soybean in Reducing Azoxymethane-Induced Aberrant Crypt Foci in Fisher 344 Male Rats
por: Gourineni, V. P., et al.
Publicado: (2011)

Chemopreventive and Antioxidant Effect of Polyphenol Free Spirulina maxima and Its Hydrolyzed Protein Content: Investigation on Azoxymethane Treated Mice
por: Martínez-Palma, Nikte Y., et al.
Publicado: (2017)

Genetics and Breeding of Lupinus mutabilis: An Emerging Protein Crop
por: Gulisano, Agata, et al.
Publicado: (2019)

Subcuticular–Intracellular Hemibiotrophy of Colletotrichum lupini in Lupinus mutabilis
por: Guilengue, Norberto, et al.
Publicado: (2022)

Onosma anatolica, a new species of Boraginaceae from Turkey
por: Binzet, Rıza
Publicado: (2016)

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax
por: Billen, Lieven P, et al.
Publicado: (2008)

The micronutrient content in underutilized crops: the Lupinus mutabilis sweet case
por: Vera-Vega, Miguel, et al.
Publicado: (2022)

Chemopreventive Effects of Germinated Rough Rice Crude Extract in Inhibiting Azoxymethane-Induced Aberrant Crypt Foci Formation in Sprague-Dawley Rats
por: Saki, Elnaz, et al.
Publicado: (2017)

Shikonin Production by Callus Culture of Onosma bulbotrichom as Active Pharmaceutical Ingredient
por: Bagheri, Fereshteh, et al.
Publicado: (2018)

Antibacterial and cytotoxic activities of naphthoquinone pigments from Onosma visianii Clem
por: Vukic, Milena D., et al.
Publicado: (2017)

Novel Anti-Aging Benzoquinone Derivatives from Onosma bracteatum Wall
por: Farooq, Umer, et al.
Publicado: (2019)

Onosma fuyunensis (Boraginaceae), a new species from Xinjiang, China
por: He, Yi, et al.
Publicado: (2020)

Component Composition and Biological Activity of Various Extracts of Onosma gmelinii (Boraginaceae)
por: Shilov, Sergey V., et al.
Publicado: (2022)

Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight
por: Kumar, Ajay, et al.
Publicado: (2022)

Expression of Apoptotic Markers Bcl-2 and Bax in the Vascular Wall
por: Klimentova, E.A., et al.
Publicado: (2021)

The prognostic significance of apoptosis-associated proteins BCL-2, BAX and BCL-X in clinical nephroblastoma
por: Ghanem, M A, et al.
Publicado: (2001)

Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia
por: Vucicevic, Ksenija, et al.
Publicado: (2016)

Chemopreventive Effect of the Germinated Oat and Its Phenolic-AVA Extract in Azoxymethane/Dextran Sulfate Sodium (AOM/DSS) Model of Colon Carcinogenesis in Mice
por: Damazo-Lima, Margarita, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kfcms2ah9his5flrj9ncb00kjo