Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes

The bone marrow niche plays an increasing role in the pathophysiogenesis of myelodysplastic syndromes. More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic stem cells leading to leukemogenesis. Extracellul...

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Detalles Bibliográficos
Autores principales: Meunier, Mathieu, Laurin, David, Park, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955013/
https://www.ncbi.nlm.nih.gov/pubmed/36831325
http://dx.doi.org/10.3390/cells12040658
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author Meunier, Mathieu
Laurin, David
Park, Sophie
author_facet Meunier, Mathieu
Laurin, David
Park, Sophie
author_sort Meunier, Mathieu
collection PubMed
description The bone marrow niche plays an increasing role in the pathophysiogenesis of myelodysplastic syndromes. More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic stem cells leading to leukemogenesis. Extracellular vesicles can mediate their miRNA and protein contents between nearby cells but also in the plasma of the patients, being potent tools for diagnosis and prognostic markers in MDS. They can be targeted by antisense miRNA or by modulators of the secretion of extracellular vesicles and could lead to future therapeutic directions in MDS.
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spelling pubmed-99550132023-02-25 Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes Meunier, Mathieu Laurin, David Park, Sophie Cells Review The bone marrow niche plays an increasing role in the pathophysiogenesis of myelodysplastic syndromes. More specifically, mesenchymal stromal cells, which can secrete extracellular vesicles and their miRNA contents, modulate the fate of hematopoietic stem cells leading to leukemogenesis. Extracellular vesicles can mediate their miRNA and protein contents between nearby cells but also in the plasma of the patients, being potent tools for diagnosis and prognostic markers in MDS. They can be targeted by antisense miRNA or by modulators of the secretion of extracellular vesicles and could lead to future therapeutic directions in MDS. MDPI 2023-02-19 /pmc/articles/PMC9955013/ /pubmed/36831325 http://dx.doi.org/10.3390/cells12040658 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Meunier, Mathieu
Laurin, David
Park, Sophie
Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title_full Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title_fullStr Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title_full_unstemmed Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title_short Extracellular Vesicles and MicroRNA in Myelodysplastic Syndromes
title_sort extracellular vesicles and microrna in myelodysplastic syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955013/
https://www.ncbi.nlm.nih.gov/pubmed/36831325
http://dx.doi.org/10.3390/cells12040658
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