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Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study

Language delays are often underestimated in very-low-birth-weight (VLBW) preterm infants. We aimed to identify the risk factors of language delay at two years of corrected age in this vulnerable population. VLBW infants, who were assessed at two years of corrected age using the Bayley Scale of Infan...

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Autores principales: Tseng, Wei-Lun, Chen, Chia-Huei, Chang, Jui-Hsing, Peng, Chun-Chih, Jim, Wai-Tim, Lin, Chia-Ying, Hsu, Chyong-Hsin, Liu, Tzu-Yu, Chang, Hung-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955016/
https://www.ncbi.nlm.nih.gov/pubmed/36832318
http://dx.doi.org/10.3390/children10020189
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author Tseng, Wei-Lun
Chen, Chia-Huei
Chang, Jui-Hsing
Peng, Chun-Chih
Jim, Wai-Tim
Lin, Chia-Ying
Hsu, Chyong-Hsin
Liu, Tzu-Yu
Chang, Hung-Yang
author_facet Tseng, Wei-Lun
Chen, Chia-Huei
Chang, Jui-Hsing
Peng, Chun-Chih
Jim, Wai-Tim
Lin, Chia-Ying
Hsu, Chyong-Hsin
Liu, Tzu-Yu
Chang, Hung-Yang
author_sort Tseng, Wei-Lun
collection PubMed
description Language delays are often underestimated in very-low-birth-weight (VLBW) preterm infants. We aimed to identify the risk factors of language delay at two years of corrected age in this vulnerable population. VLBW infants, who were assessed at two years of corrected age using the Bayley Scale of Infant Development, third edition, were included using a population-based cohort database. Language delay was defined as mild to moderate if the composite score was between 70 and 85 and severe if the score was < 70. Multivariable logistic regression analysis was used to identify the perinatal risk factors associated with language delay. The study comprised 3797 VLBW preterm infants; 678 (18%) had a mild to moderate delay and 235 (6%) had a severe delay. After adjusting for confounding factors, low maternal education level, low maternal socioeconomic status, extremely low birth weight, male sex, and severe intraventricular hemorrhage (IVH) and/or cystic periventricular leukomalacia (PVL) were found to be significantly associated with both mild to moderate and severe delays. Resuscitation at delivery, necrotizing enterocolitis, and patent ductus arteriosus requiring ligation showed significant associations with severe delay. The strongest factors predicting both mild to moderate and severe language delays were the male sex and severe IVH and/or cystic PVL; thus, early targeted intervention is warranted in these populations.
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spelling pubmed-99550162023-02-25 Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study Tseng, Wei-Lun Chen, Chia-Huei Chang, Jui-Hsing Peng, Chun-Chih Jim, Wai-Tim Lin, Chia-Ying Hsu, Chyong-Hsin Liu, Tzu-Yu Chang, Hung-Yang Children (Basel) Article Language delays are often underestimated in very-low-birth-weight (VLBW) preterm infants. We aimed to identify the risk factors of language delay at two years of corrected age in this vulnerable population. VLBW infants, who were assessed at two years of corrected age using the Bayley Scale of Infant Development, third edition, were included using a population-based cohort database. Language delay was defined as mild to moderate if the composite score was between 70 and 85 and severe if the score was < 70. Multivariable logistic regression analysis was used to identify the perinatal risk factors associated with language delay. The study comprised 3797 VLBW preterm infants; 678 (18%) had a mild to moderate delay and 235 (6%) had a severe delay. After adjusting for confounding factors, low maternal education level, low maternal socioeconomic status, extremely low birth weight, male sex, and severe intraventricular hemorrhage (IVH) and/or cystic periventricular leukomalacia (PVL) were found to be significantly associated with both mild to moderate and severe delays. Resuscitation at delivery, necrotizing enterocolitis, and patent ductus arteriosus requiring ligation showed significant associations with severe delay. The strongest factors predicting both mild to moderate and severe language delays were the male sex and severe IVH and/or cystic PVL; thus, early targeted intervention is warranted in these populations. MDPI 2023-01-19 /pmc/articles/PMC9955016/ /pubmed/36832318 http://dx.doi.org/10.3390/children10020189 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tseng, Wei-Lun
Chen, Chia-Huei
Chang, Jui-Hsing
Peng, Chun-Chih
Jim, Wai-Tim
Lin, Chia-Ying
Hsu, Chyong-Hsin
Liu, Tzu-Yu
Chang, Hung-Yang
Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title_full Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title_fullStr Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title_full_unstemmed Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title_short Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study
title_sort risk factors of language delay at two years of corrected age among very-low-birth-weight preterm infants: a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955016/
https://www.ncbi.nlm.nih.gov/pubmed/36832318
http://dx.doi.org/10.3390/children10020189
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