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Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome

Background: To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. Methods: Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspected coronary artery disease (CAD) who un...

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Autores principales: Ebersberger, Ullrich, Bauer, Maximilian J., Straube, Florian, Fink, Nicola, Schoepf, U. Joseph, Varga-Szemes, Akos, Emrich, Tilman, Griffith, Joseph, Hoffmann, Ellen, Tesche, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955054/
https://www.ncbi.nlm.nih.gov/pubmed/36832112
http://dx.doi.org/10.3390/diagnostics13040624
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author Ebersberger, Ullrich
Bauer, Maximilian J.
Straube, Florian
Fink, Nicola
Schoepf, U. Joseph
Varga-Szemes, Akos
Emrich, Tilman
Griffith, Joseph
Hoffmann, Ellen
Tesche, Christian
author_facet Ebersberger, Ullrich
Bauer, Maximilian J.
Straube, Florian
Fink, Nicola
Schoepf, U. Joseph
Varga-Szemes, Akos
Emrich, Tilman
Griffith, Joseph
Hoffmann, Ellen
Tesche, Christian
author_sort Ebersberger, Ullrich
collection PubMed
description Background: To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. Methods: Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspected coronary artery disease (CAD) who underwent CCTA were retrospectively analyzed. EAT volume and plaque composition from CCTA were compared between men and women. Major adverse cardiovascular events (MACE) were recorded from follow-up. Results: Men were more likely to have obstructive CAD, higher Agatston scores, and a larger total and non-calcified plaque burden. In addition, men displayed more adverse plaque characteristics and EAT volume compared to women (all p < 0.05). After a median follow-up of 5.1 years, MACE occurred in 8 women (6%) and 22 men (10%). In multivariable analysis, Agatston calcium score (HR 1.0008, p = 0.014), EAT volume (HR 1.067, p = 0.049), and low-attenuation plaque (HR 3.82, p = 0.036) were independent predictors for MACE in men, whereas only low-attenuation plaque (HR 2.42, p = 0.041) showed predictive value for events in women. Conclusion: Women demonstrated less overall plaque burden, fewer adverse plaque characteristics, and a smaller EAT volume compared to men. However, low-attenuation plaque is a predictor for MACE in both genders. Thus, a differentiated plaque analysis is warranted to understand gender differences of atherosclerosis to guide medical therapy and prevention strategies.
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spelling pubmed-99550542023-02-25 Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome Ebersberger, Ullrich Bauer, Maximilian J. Straube, Florian Fink, Nicola Schoepf, U. Joseph Varga-Szemes, Akos Emrich, Tilman Griffith, Joseph Hoffmann, Ellen Tesche, Christian Diagnostics (Basel) Article Background: To investigate gender differences in epicardial adipose tissue (EAT) and plaque composition by coronary CT angiography (CCTA) and the association with cardiovascular outcome. Methods: Data of 352 patients (64.2 ± 10.3 years, 38% female) with suspected coronary artery disease (CAD) who underwent CCTA were retrospectively analyzed. EAT volume and plaque composition from CCTA were compared between men and women. Major adverse cardiovascular events (MACE) were recorded from follow-up. Results: Men were more likely to have obstructive CAD, higher Agatston scores, and a larger total and non-calcified plaque burden. In addition, men displayed more adverse plaque characteristics and EAT volume compared to women (all p < 0.05). After a median follow-up of 5.1 years, MACE occurred in 8 women (6%) and 22 men (10%). In multivariable analysis, Agatston calcium score (HR 1.0008, p = 0.014), EAT volume (HR 1.067, p = 0.049), and low-attenuation plaque (HR 3.82, p = 0.036) were independent predictors for MACE in men, whereas only low-attenuation plaque (HR 2.42, p = 0.041) showed predictive value for events in women. Conclusion: Women demonstrated less overall plaque burden, fewer adverse plaque characteristics, and a smaller EAT volume compared to men. However, low-attenuation plaque is a predictor for MACE in both genders. Thus, a differentiated plaque analysis is warranted to understand gender differences of atherosclerosis to guide medical therapy and prevention strategies. MDPI 2023-02-08 /pmc/articles/PMC9955054/ /pubmed/36832112 http://dx.doi.org/10.3390/diagnostics13040624 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ebersberger, Ullrich
Bauer, Maximilian J.
Straube, Florian
Fink, Nicola
Schoepf, U. Joseph
Varga-Szemes, Akos
Emrich, Tilman
Griffith, Joseph
Hoffmann, Ellen
Tesche, Christian
Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title_full Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title_fullStr Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title_full_unstemmed Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title_short Gender Differences in Epicardial Adipose Tissue and Plaque Composition by Coronary CT Angiography: Association with Cardiovascular Outcome
title_sort gender differences in epicardial adipose tissue and plaque composition by coronary ct angiography: association with cardiovascular outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955054/
https://www.ncbi.nlm.nih.gov/pubmed/36832112
http://dx.doi.org/10.3390/diagnostics13040624
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