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Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?

Background: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners. Methods: An anthropomorphic chest phantom containing fourteen differen...

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Autores principales: Gross, Colin F., Jungblut, Lisa, Schindera, Sebastian, Messerli, Michael, Fretz, Valentin, Frauenfelder, Thomas, Martini, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955074/
https://www.ncbi.nlm.nih.gov/pubmed/36832118
http://dx.doi.org/10.3390/diagnostics13040631
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author Gross, Colin F.
Jungblut, Lisa
Schindera, Sebastian
Messerli, Michael
Fretz, Valentin
Frauenfelder, Thomas
Martini, Katharina
author_facet Gross, Colin F.
Jungblut, Lisa
Schindera, Sebastian
Messerli, Michael
Fretz, Valentin
Frauenfelder, Thomas
Martini, Katharina
author_sort Gross, Colin F.
collection PubMed
description Background: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners. Methods: An anthropomorphic chest phantom containing fourteen different-sized (range 3–12 mm) and CT-attenuated (100 HU, −630 HU and −800 HU, termed as solid, GG1 and GG2) pulmonary nodules was imaged on five CT scanners with institute-specific standard protocols (P(S)) and the lung cancer screening protocol recommended by ESTI (ESTI protocol, P(E)). Images were reconstructed with filtered back projection (FBP) and iterative reconstruction (REC). Image noise, nodule density and size (diameter/volume) were measured. Absolute percentage errors (APEs) of measurements were calculated. Results: Using P(E), dosage variance between different scanners tended to decrease compared to P(S), and the mean differences were statistically insignificant (p = 0.48). P(S) and P(E(REC)) showed significantly less image noise than P(E(FBP)) (p < 0.001). The smallest size measurement errors were noted with volumetric measurements in P(E(REC)) and highest with diametric measurements in P(E(FBP)). Volume performed better than diameter measurements in solid and GG1 nodules (p < 0.001). However, in GG2 nodules, this could not be observed (p = 0.20). Regarding nodule density, REC values were more consistent throughout different scanners and protocols. Conclusion: Considering radiation dose, image noise, nodule size, and density measurements, we fully endorse the ESTI screening protocol including the use of REC. For size measurements, volume should be preferred over diameter.
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spelling pubmed-99550742023-02-25 Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume? Gross, Colin F. Jungblut, Lisa Schindera, Sebastian Messerli, Michael Fretz, Valentin Frauenfelder, Thomas Martini, Katharina Diagnostics (Basel) Article Background: To assess the impact of the lung cancer screening protocol recommended by the European Society of Thoracic Imaging (ESTI) on nodule diameter, volume, and density throughout different computed tomography (CT) scanners. Methods: An anthropomorphic chest phantom containing fourteen different-sized (range 3–12 mm) and CT-attenuated (100 HU, −630 HU and −800 HU, termed as solid, GG1 and GG2) pulmonary nodules was imaged on five CT scanners with institute-specific standard protocols (P(S)) and the lung cancer screening protocol recommended by ESTI (ESTI protocol, P(E)). Images were reconstructed with filtered back projection (FBP) and iterative reconstruction (REC). Image noise, nodule density and size (diameter/volume) were measured. Absolute percentage errors (APEs) of measurements were calculated. Results: Using P(E), dosage variance between different scanners tended to decrease compared to P(S), and the mean differences were statistically insignificant (p = 0.48). P(S) and P(E(REC)) showed significantly less image noise than P(E(FBP)) (p < 0.001). The smallest size measurement errors were noted with volumetric measurements in P(E(REC)) and highest with diametric measurements in P(E(FBP)). Volume performed better than diameter measurements in solid and GG1 nodules (p < 0.001). However, in GG2 nodules, this could not be observed (p = 0.20). Regarding nodule density, REC values were more consistent throughout different scanners and protocols. Conclusion: Considering radiation dose, image noise, nodule size, and density measurements, we fully endorse the ESTI screening protocol including the use of REC. For size measurements, volume should be preferred over diameter. MDPI 2023-02-08 /pmc/articles/PMC9955074/ /pubmed/36832118 http://dx.doi.org/10.3390/diagnostics13040631 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gross, Colin F.
Jungblut, Lisa
Schindera, Sebastian
Messerli, Michael
Fretz, Valentin
Frauenfelder, Thomas
Martini, Katharina
Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title_full Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title_fullStr Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title_full_unstemmed Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title_short Comparability of Pulmonary Nodule Size Measurements among Different Scanners and Protocols: Should Diameter Be Favorized over Volume?
title_sort comparability of pulmonary nodule size measurements among different scanners and protocols: should diameter be favorized over volume?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955074/
https://www.ncbi.nlm.nih.gov/pubmed/36832118
http://dx.doi.org/10.3390/diagnostics13040631
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