Cargando…

Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population

(1) Background and Purpose: The aim of this study was to retrospectively characterize WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, in order to learn more about the spectrum of the underlying disorders encountered in everyday clinical practice. (2) Materials and M...

Descripción completa

Detalles Bibliográficos
Autores principales: Wenger, Katharina J., Koldijk, Caroline E., Hattingen, Elke, Porto, Luciana, Kurre, Wiebke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955075/
https://www.ncbi.nlm.nih.gov/pubmed/36832335
http://dx.doi.org/10.3390/children10020206
_version_ 1784894267754283008
author Wenger, Katharina J.
Koldijk, Caroline E.
Hattingen, Elke
Porto, Luciana
Kurre, Wiebke
author_facet Wenger, Katharina J.
Koldijk, Caroline E.
Hattingen, Elke
Porto, Luciana
Kurre, Wiebke
author_sort Wenger, Katharina J.
collection PubMed
description (1) Background and Purpose: The aim of this study was to retrospectively characterize WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, in order to learn more about the spectrum of the underlying disorders encountered in everyday clinical practice. (2) Materials and Methods: Radiology reports of 5166 consecutive patients with standard brain MRI (2006–2018) were searched for predefined keywords describing WMSAs. A neuroradiology specialist enrolled patients with WMSAs following a structured approach. Imaging characteristics, etiology (autoimmune disorders, non-genetic hypoxic and ischemic insults, traumatic white matter injuries, no final diagnosis due to insufficient clinical information, “non-specific” WMSAs, infectious white matter damage, leukodystrophies, toxic white matter injuries, inborn errors of metabolism, and white matter damage caused by tumor infiltration/cancer-like disease), and age/gender distribution were evaluated. (3) Results: Overall, WMSAs were found in 3.4% of pediatric patients scanned at our and referring hospitals within the ten-year study period. The majority were found in the supratentorial region only (87%) and were non-enhancing (78% of CE-MRI). WMSAs caused by autoimmune disorders formed the largest group (23%), followed by “non-specific” WMSAs (18%), as well as non-genetic hypoxic and ischemic insults (17%). The majority were therefore acquired as opposed to inherited. Etiology-based classification of WMSAs was affected by age but not by gender. In 17% of the study population, a definite diagnosis could not be established due to insufficient clinical information (mostly external radiology consults). (4) Conclusions: An “integrated diagnosis” that combines baseline demographics, including patient age as an important factor, clinical characteristics, and additional diagnostic workup with imaging patterns can be made in the majority of cases.
format Online
Article
Text
id pubmed-9955075
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99550752023-02-25 Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population Wenger, Katharina J. Koldijk, Caroline E. Hattingen, Elke Porto, Luciana Kurre, Wiebke Children (Basel) Article (1) Background and Purpose: The aim of this study was to retrospectively characterize WMSAs in an unselected patient cohort at a large pediatric neuroimaging facility, in order to learn more about the spectrum of the underlying disorders encountered in everyday clinical practice. (2) Materials and Methods: Radiology reports of 5166 consecutive patients with standard brain MRI (2006–2018) were searched for predefined keywords describing WMSAs. A neuroradiology specialist enrolled patients with WMSAs following a structured approach. Imaging characteristics, etiology (autoimmune disorders, non-genetic hypoxic and ischemic insults, traumatic white matter injuries, no final diagnosis due to insufficient clinical information, “non-specific” WMSAs, infectious white matter damage, leukodystrophies, toxic white matter injuries, inborn errors of metabolism, and white matter damage caused by tumor infiltration/cancer-like disease), and age/gender distribution were evaluated. (3) Results: Overall, WMSAs were found in 3.4% of pediatric patients scanned at our and referring hospitals within the ten-year study period. The majority were found in the supratentorial region only (87%) and were non-enhancing (78% of CE-MRI). WMSAs caused by autoimmune disorders formed the largest group (23%), followed by “non-specific” WMSAs (18%), as well as non-genetic hypoxic and ischemic insults (17%). The majority were therefore acquired as opposed to inherited. Etiology-based classification of WMSAs was affected by age but not by gender. In 17% of the study population, a definite diagnosis could not be established due to insufficient clinical information (mostly external radiology consults). (4) Conclusions: An “integrated diagnosis” that combines baseline demographics, including patient age as an important factor, clinical characteristics, and additional diagnostic workup with imaging patterns can be made in the majority of cases. MDPI 2023-01-24 /pmc/articles/PMC9955075/ /pubmed/36832335 http://dx.doi.org/10.3390/children10020206 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wenger, Katharina J.
Koldijk, Caroline E.
Hattingen, Elke
Porto, Luciana
Kurre, Wiebke
Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title_full Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title_fullStr Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title_full_unstemmed Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title_short Characterization of MRI White Matter Signal Abnormalities in the Pediatric Population
title_sort characterization of mri white matter signal abnormalities in the pediatric population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955075/
https://www.ncbi.nlm.nih.gov/pubmed/36832335
http://dx.doi.org/10.3390/children10020206
work_keys_str_mv AT wengerkatharinaj characterizationofmriwhitemattersignalabnormalitiesinthepediatricpopulation
AT koldijkcarolinee characterizationofmriwhitemattersignalabnormalitiesinthepediatricpopulation
AT hattingenelke characterizationofmriwhitemattersignalabnormalitiesinthepediatricpopulation
AT portoluciana characterizationofmriwhitemattersignalabnormalitiesinthepediatricpopulation
AT kurrewiebke characterizationofmriwhitemattersignalabnormalitiesinthepediatricpopulation