Cargando…

Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer

Background: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim...

Descripción completa

Detalles Bibliográficos
Autores principales: Christodoulidis, Grigorios, Halliday, Laura J., Samara, Athina, Bhuva, Neel, Park, Won-Ho Edward, Moorthy, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955115/
https://www.ncbi.nlm.nih.gov/pubmed/36826079
http://dx.doi.org/10.3390/curroncol30020118
_version_ 1784894277612994560
author Christodoulidis, Grigorios
Halliday, Laura J.
Samara, Athina
Bhuva, Neel
Park, Won-Ho Edward
Moorthy, Krishna
author_facet Christodoulidis, Grigorios
Halliday, Laura J.
Samara, Athina
Bhuva, Neel
Park, Won-Ho Edward
Moorthy, Krishna
author_sort Christodoulidis, Grigorios
collection PubMed
description Background: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim of this study was to assess the impact of prehabilitation on the tolerance of neoadjuvant chemotherapy in patients with oesophageal cancer. Methods: Patients with oesophageal or gastroesophageal junction (GOJ) cancer from two oncology centres were retrospectively included in the present comparative cohort study; one provided a multimodal prehabilitation programme and one did not offer any prehabilitation. Tolerance of chemotherapy, defined as completion of the full chemotherapy regime as per protocol, was compared between the two groups. Results: In terms of participants, 92 patients were included in this study, 47 patients in the prehabilitation cohort and 45 in the control cohort. Compared with the control group, the prehabilitation group demonstrated an improved rate of chemotherapy completion (p = 0.029). In multivariate analysis, participation in prehabilitation was significantly associated with an improved rate of chemotherapy completion. Conclusion: The findings of this exploratory study suggest that prehabilitation is associated with better tolerance for chemotherapy. Further research is needed to establish the long-term impact of prehabilitation on oncological outcomes.
format Online
Article
Text
id pubmed-9955115
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99551152023-02-25 Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer Christodoulidis, Grigorios Halliday, Laura J. Samara, Athina Bhuva, Neel Park, Won-Ho Edward Moorthy, Krishna Curr Oncol Communication Background: Prehabilitation programmes aim to optimise patients before and after cancer treatment including surgery. Previous studies in surgical patients demonstrate that prehabilitation improves pre-operative fitness and overcomes the negative impact of neoadjuvant chemotherapy on fitness. The aim of this study was to assess the impact of prehabilitation on the tolerance of neoadjuvant chemotherapy in patients with oesophageal cancer. Methods: Patients with oesophageal or gastroesophageal junction (GOJ) cancer from two oncology centres were retrospectively included in the present comparative cohort study; one provided a multimodal prehabilitation programme and one did not offer any prehabilitation. Tolerance of chemotherapy, defined as completion of the full chemotherapy regime as per protocol, was compared between the two groups. Results: In terms of participants, 92 patients were included in this study, 47 patients in the prehabilitation cohort and 45 in the control cohort. Compared with the control group, the prehabilitation group demonstrated an improved rate of chemotherapy completion (p = 0.029). In multivariate analysis, participation in prehabilitation was significantly associated with an improved rate of chemotherapy completion. Conclusion: The findings of this exploratory study suggest that prehabilitation is associated with better tolerance for chemotherapy. Further research is needed to establish the long-term impact of prehabilitation on oncological outcomes. MDPI 2023-01-24 /pmc/articles/PMC9955115/ /pubmed/36826079 http://dx.doi.org/10.3390/curroncol30020118 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Christodoulidis, Grigorios
Halliday, Laura J.
Samara, Athina
Bhuva, Neel
Park, Won-Ho Edward
Moorthy, Krishna
Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title_full Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title_fullStr Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title_full_unstemmed Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title_short Personalized Prehabilitation Improves Tolerance to Chemotherapy in Patients with Oesophageal Cancer
title_sort personalized prehabilitation improves tolerance to chemotherapy in patients with oesophageal cancer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955115/
https://www.ncbi.nlm.nih.gov/pubmed/36826079
http://dx.doi.org/10.3390/curroncol30020118
work_keys_str_mv AT christodoulidisgrigorios personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer
AT hallidaylauraj personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer
AT samaraathina personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer
AT bhuvaneel personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer
AT parkwonhoedward personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer
AT moorthykrishna personalizedprehabilitationimprovestolerancetochemotherapyinpatientswithoesophagealcancer