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Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accu...

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Detalles Bibliográficos
Autores principales: Rabaan, Ali A., AlSaihati, Hajir, Bukhamsin, Rehab, Bakhrebah, Muhammed A., Nassar, Majed S., Alsaleh, Abdulmonem A., Alhashem, Yousef N., Bukhamseen, Ammar Y., Al-Ruhimy, Khalil, Alotaibi, Mohammed, Alsubki, Roua A., Alahmed, Hejji E., Al-Abdulhadi, Saleh, Alhashem, Fatemah A., Alqatari, Ahlam A., Alsayyah, Ahmed, Farahat, Ramadan Abdelmoez, Abdulal, Rwaa H., Al-Ahmed, Ali H., Imran, Mohd., Mohapatra, Ranjan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955208/
https://www.ncbi.nlm.nih.gov/pubmed/36826113
http://dx.doi.org/10.3390/curroncol30020152
Descripción
Sumario:Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.