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Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accu...

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Autores principales: Rabaan, Ali A., AlSaihati, Hajir, Bukhamsin, Rehab, Bakhrebah, Muhammed A., Nassar, Majed S., Alsaleh, Abdulmonem A., Alhashem, Yousef N., Bukhamseen, Ammar Y., Al-Ruhimy, Khalil, Alotaibi, Mohammed, Alsubki, Roua A., Alahmed, Hejji E., Al-Abdulhadi, Saleh, Alhashem, Fatemah A., Alqatari, Ahlam A., Alsayyah, Ahmed, Farahat, Ramadan Abdelmoez, Abdulal, Rwaa H., Al-Ahmed, Ali H., Imran, Mohd., Mohapatra, Ranjan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955208/
https://www.ncbi.nlm.nih.gov/pubmed/36826113
http://dx.doi.org/10.3390/curroncol30020152
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author Rabaan, Ali A.
AlSaihati, Hajir
Bukhamsin, Rehab
Bakhrebah, Muhammed A.
Nassar, Majed S.
Alsaleh, Abdulmonem A.
Alhashem, Yousef N.
Bukhamseen, Ammar Y.
Al-Ruhimy, Khalil
Alotaibi, Mohammed
Alsubki, Roua A.
Alahmed, Hejji E.
Al-Abdulhadi, Saleh
Alhashem, Fatemah A.
Alqatari, Ahlam A.
Alsayyah, Ahmed
Farahat, Ramadan Abdelmoez
Abdulal, Rwaa H.
Al-Ahmed, Ali H.
Imran, Mohd.
Mohapatra, Ranjan K.
author_facet Rabaan, Ali A.
AlSaihati, Hajir
Bukhamsin, Rehab
Bakhrebah, Muhammed A.
Nassar, Majed S.
Alsaleh, Abdulmonem A.
Alhashem, Yousef N.
Bukhamseen, Ammar Y.
Al-Ruhimy, Khalil
Alotaibi, Mohammed
Alsubki, Roua A.
Alahmed, Hejji E.
Al-Abdulhadi, Saleh
Alhashem, Fatemah A.
Alqatari, Ahlam A.
Alsayyah, Ahmed
Farahat, Ramadan Abdelmoez
Abdulal, Rwaa H.
Al-Ahmed, Ali H.
Imran, Mohd.
Mohapatra, Ranjan K.
author_sort Rabaan, Ali A.
collection PubMed
description Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.
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spelling pubmed-99552082023-02-25 Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction Rabaan, Ali A. AlSaihati, Hajir Bukhamsin, Rehab Bakhrebah, Muhammed A. Nassar, Majed S. Alsaleh, Abdulmonem A. Alhashem, Yousef N. Bukhamseen, Ammar Y. Al-Ruhimy, Khalil Alotaibi, Mohammed Alsubki, Roua A. Alahmed, Hejji E. Al-Abdulhadi, Saleh Alhashem, Fatemah A. Alqatari, Ahlam A. Alsayyah, Ahmed Farahat, Ramadan Abdelmoez Abdulal, Rwaa H. Al-Ahmed, Ali H. Imran, Mohd. Mohapatra, Ranjan K. Curr Oncol Review Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment. MDPI 2023-02-06 /pmc/articles/PMC9955208/ /pubmed/36826113 http://dx.doi.org/10.3390/curroncol30020152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rabaan, Ali A.
AlSaihati, Hajir
Bukhamsin, Rehab
Bakhrebah, Muhammed A.
Nassar, Majed S.
Alsaleh, Abdulmonem A.
Alhashem, Yousef N.
Bukhamseen, Ammar Y.
Al-Ruhimy, Khalil
Alotaibi, Mohammed
Alsubki, Roua A.
Alahmed, Hejji E.
Al-Abdulhadi, Saleh
Alhashem, Fatemah A.
Alqatari, Ahlam A.
Alsayyah, Ahmed
Farahat, Ramadan Abdelmoez
Abdulal, Rwaa H.
Al-Ahmed, Ali H.
Imran, Mohd.
Mohapatra, Ranjan K.
Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title_full Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title_fullStr Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title_full_unstemmed Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title_short Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
title_sort application of crispr/cas9 technology in cancer treatment: a future direction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955208/
https://www.ncbi.nlm.nih.gov/pubmed/36826113
http://dx.doi.org/10.3390/curroncol30020152
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