Cargando…
Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accu...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955208/ https://www.ncbi.nlm.nih.gov/pubmed/36826113 http://dx.doi.org/10.3390/curroncol30020152 |
_version_ | 1784894298377945088 |
---|---|
author | Rabaan, Ali A. AlSaihati, Hajir Bukhamsin, Rehab Bakhrebah, Muhammed A. Nassar, Majed S. Alsaleh, Abdulmonem A. Alhashem, Yousef N. Bukhamseen, Ammar Y. Al-Ruhimy, Khalil Alotaibi, Mohammed Alsubki, Roua A. Alahmed, Hejji E. Al-Abdulhadi, Saleh Alhashem, Fatemah A. Alqatari, Ahlam A. Alsayyah, Ahmed Farahat, Ramadan Abdelmoez Abdulal, Rwaa H. Al-Ahmed, Ali H. Imran, Mohd. Mohapatra, Ranjan K. |
author_facet | Rabaan, Ali A. AlSaihati, Hajir Bukhamsin, Rehab Bakhrebah, Muhammed A. Nassar, Majed S. Alsaleh, Abdulmonem A. Alhashem, Yousef N. Bukhamseen, Ammar Y. Al-Ruhimy, Khalil Alotaibi, Mohammed Alsubki, Roua A. Alahmed, Hejji E. Al-Abdulhadi, Saleh Alhashem, Fatemah A. Alqatari, Ahlam A. Alsayyah, Ahmed Farahat, Ramadan Abdelmoez Abdulal, Rwaa H. Al-Ahmed, Ali H. Imran, Mohd. Mohapatra, Ranjan K. |
author_sort | Rabaan, Ali A. |
collection | PubMed |
description | Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment. |
format | Online Article Text |
id | pubmed-9955208 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99552082023-02-25 Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction Rabaan, Ali A. AlSaihati, Hajir Bukhamsin, Rehab Bakhrebah, Muhammed A. Nassar, Majed S. Alsaleh, Abdulmonem A. Alhashem, Yousef N. Bukhamseen, Ammar Y. Al-Ruhimy, Khalil Alotaibi, Mohammed Alsubki, Roua A. Alahmed, Hejji E. Al-Abdulhadi, Saleh Alhashem, Fatemah A. Alqatari, Ahlam A. Alsayyah, Ahmed Farahat, Ramadan Abdelmoez Abdulal, Rwaa H. Al-Ahmed, Ali H. Imran, Mohd. Mohapatra, Ranjan K. Curr Oncol Review Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment. MDPI 2023-02-06 /pmc/articles/PMC9955208/ /pubmed/36826113 http://dx.doi.org/10.3390/curroncol30020152 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rabaan, Ali A. AlSaihati, Hajir Bukhamsin, Rehab Bakhrebah, Muhammed A. Nassar, Majed S. Alsaleh, Abdulmonem A. Alhashem, Yousef N. Bukhamseen, Ammar Y. Al-Ruhimy, Khalil Alotaibi, Mohammed Alsubki, Roua A. Alahmed, Hejji E. Al-Abdulhadi, Saleh Alhashem, Fatemah A. Alqatari, Ahlam A. Alsayyah, Ahmed Farahat, Ramadan Abdelmoez Abdulal, Rwaa H. Al-Ahmed, Ali H. Imran, Mohd. Mohapatra, Ranjan K. Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title | Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title_full | Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title_fullStr | Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title_full_unstemmed | Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title_short | Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction |
title_sort | application of crispr/cas9 technology in cancer treatment: a future direction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955208/ https://www.ncbi.nlm.nih.gov/pubmed/36826113 http://dx.doi.org/10.3390/curroncol30020152 |
work_keys_str_mv | AT rabaanalia applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alsaihatihajir applicationofcrisprcas9technologyincancertreatmentafuturedirection AT bukhamsinrehab applicationofcrisprcas9technologyincancertreatmentafuturedirection AT bakhrebahmuhammeda applicationofcrisprcas9technologyincancertreatmentafuturedirection AT nassarmajeds applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alsalehabdulmonema applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alhashemyousefn applicationofcrisprcas9technologyincancertreatmentafuturedirection AT bukhamseenammary applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alruhimykhalil applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alotaibimohammed applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alsubkirouaa applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alahmedhejjie applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alabdulhadisaleh applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alhashemfatemaha applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alqatariahlama applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alsayyahahmed applicationofcrisprcas9technologyincancertreatmentafuturedirection AT farahatramadanabdelmoez applicationofcrisprcas9technologyincancertreatmentafuturedirection AT abdulalrwaah applicationofcrisprcas9technologyincancertreatmentafuturedirection AT alahmedalih applicationofcrisprcas9technologyincancertreatmentafuturedirection AT imranmohd applicationofcrisprcas9technologyincancertreatmentafuturedirection AT mohapatraranjank applicationofcrisprcas9technologyincancertreatmentafuturedirection |