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Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma

Background: The prognostic importance of osteopenia in patients with intrahepatic cholangiocarcinoma (ICC) undergoing hepatectomy is unclear. The aim of this study was to evaluate the impact of osteopenia on survival in patients with ICC. Methods: A total of 71 patients who underwent hepatectomy at...

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Autores principales: Miki, Atsushi, Sakuma, Yasunaru, Watanabe, Jun, Endo, Kazuhiro, Sasanuma, Hideki, Teratani, Takumi, Lefor, Alan Kawarai, Kitayama, Joji, Sata, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955432/
https://www.ncbi.nlm.nih.gov/pubmed/36826105
http://dx.doi.org/10.3390/curroncol30020144
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author Miki, Atsushi
Sakuma, Yasunaru
Watanabe, Jun
Endo, Kazuhiro
Sasanuma, Hideki
Teratani, Takumi
Lefor, Alan Kawarai
Kitayama, Joji
Sata, Naohiro
author_facet Miki, Atsushi
Sakuma, Yasunaru
Watanabe, Jun
Endo, Kazuhiro
Sasanuma, Hideki
Teratani, Takumi
Lefor, Alan Kawarai
Kitayama, Joji
Sata, Naohiro
author_sort Miki, Atsushi
collection PubMed
description Background: The prognostic importance of osteopenia in patients with intrahepatic cholangiocarcinoma (ICC) undergoing hepatectomy is unclear. The aim of this study was to evaluate the impact of osteopenia on survival in patients with ICC. Methods: A total of 71 patients who underwent hepatectomy at Jichi Medical University between July 2008 and June 2022 were included in this study. Non-contrast computed tomography scan images at the eleventh thoracic vertebra were used to assess bone mineral density. The cutoff value was calculated using a threshold value of 160 Hounsfield units. Overall survival curves were made using the Kaplan–Meier method and the log-rank test was used to evaluate survival. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival were calculated using Cox’s proportional hazard model. Results: In multivariable analysis, osteopenia (HR 3.66, 95%CI 1.16–14.1, p = 0.0258) and the platelet–lymphocyte ratio (HR 6.26, 95%CI 2.27–15.9, p = 0.0008) were significant independent factors associated with overall survival. There were no significant independent prognostic factors for recurrence-free survival. Conclusions: Preoperative osteopenia is significantly associated with postoperative survival in patients with ICC undergoing hepatectomy.
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spelling pubmed-99554322023-02-25 Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma Miki, Atsushi Sakuma, Yasunaru Watanabe, Jun Endo, Kazuhiro Sasanuma, Hideki Teratani, Takumi Lefor, Alan Kawarai Kitayama, Joji Sata, Naohiro Curr Oncol Article Background: The prognostic importance of osteopenia in patients with intrahepatic cholangiocarcinoma (ICC) undergoing hepatectomy is unclear. The aim of this study was to evaluate the impact of osteopenia on survival in patients with ICC. Methods: A total of 71 patients who underwent hepatectomy at Jichi Medical University between July 2008 and June 2022 were included in this study. Non-contrast computed tomography scan images at the eleventh thoracic vertebra were used to assess bone mineral density. The cutoff value was calculated using a threshold value of 160 Hounsfield units. Overall survival curves were made using the Kaplan–Meier method and the log-rank test was used to evaluate survival. The hazard ratio (HR) and 95% confidence interval (CI) for overall survival were calculated using Cox’s proportional hazard model. Results: In multivariable analysis, osteopenia (HR 3.66, 95%CI 1.16–14.1, p = 0.0258) and the platelet–lymphocyte ratio (HR 6.26, 95%CI 2.27–15.9, p = 0.0008) were significant independent factors associated with overall survival. There were no significant independent prognostic factors for recurrence-free survival. Conclusions: Preoperative osteopenia is significantly associated with postoperative survival in patients with ICC undergoing hepatectomy. MDPI 2023-02-02 /pmc/articles/PMC9955432/ /pubmed/36826105 http://dx.doi.org/10.3390/curroncol30020144 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miki, Atsushi
Sakuma, Yasunaru
Watanabe, Jun
Endo, Kazuhiro
Sasanuma, Hideki
Teratani, Takumi
Lefor, Alan Kawarai
Kitayama, Joji
Sata, Naohiro
Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title_full Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title_fullStr Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title_full_unstemmed Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title_short Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma
title_sort osteopenia is associated with shorter survival in patients with intrahepatic cholangiocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955432/
https://www.ncbi.nlm.nih.gov/pubmed/36826105
http://dx.doi.org/10.3390/curroncol30020144
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