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Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions
Dermatofibroma (DF) or fibrous histiocytoma is one of the most frequent benign cutaneous soft-tissue lesions, characterized by a post-inflammatory tissue reaction associated with fibrosis of the dermis. Clinically DFs have a polymorphous clinical aspect from the solitary, firm, single nodules to mul...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955442/ https://www.ncbi.nlm.nih.gov/pubmed/36832159 http://dx.doi.org/10.3390/diagnostics13040671 |
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author | Orzan, Olguța Anca Dorobanțu, Alexandra Maria Gurău, Cristian Dorin Ali, Sibel Mihai, Mara Mădălina Popa, Liliana Gabriela Giurcăneanu, Călin Tudose, Irina Bălăceanu, Beatrice |
author_facet | Orzan, Olguța Anca Dorobanțu, Alexandra Maria Gurău, Cristian Dorin Ali, Sibel Mihai, Mara Mădălina Popa, Liliana Gabriela Giurcăneanu, Călin Tudose, Irina Bălăceanu, Beatrice |
author_sort | Orzan, Olguța Anca |
collection | PubMed |
description | Dermatofibroma (DF) or fibrous histiocytoma is one of the most frequent benign cutaneous soft-tissue lesions, characterized by a post-inflammatory tissue reaction associated with fibrosis of the dermis. Clinically DFs have a polymorphous clinical aspect from the solitary, firm, single nodules to multiple papules with a relatively smooth surface. However, multiple atypical clinicopathological variants of DFs have been reported and, therefore, clinical recognition may become challenging, leading to a more burdensome identification and sometimes to misdiagnosis. Dermoscopy is considered an important tool in DFs diagnosis, as it improves diagnostic accuracy for clinically amelanotic nodules. Although typical dermoscopic patterns are most frequently seen in clinical practice, there have also been some atypical variants described, mimicking some underlying recurrent and sometimes harmful skin afflictions. Usually, no treatment is required, although an appropriate work-up may be necessary in specific cases, such as in the presence of atypical variants or a history of recent changes. This narrative review’s aim is to summarize current evidence regarding clinical presentation, positive and differential diagnosis of atypical dermatofibromas and also to raise awareness about the importance of specific characteristics of atypical variants to better differentiate them from malignant conditions. |
format | Online Article Text |
id | pubmed-9955442 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99554422023-02-25 Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions Orzan, Olguța Anca Dorobanțu, Alexandra Maria Gurău, Cristian Dorin Ali, Sibel Mihai, Mara Mădălina Popa, Liliana Gabriela Giurcăneanu, Călin Tudose, Irina Bălăceanu, Beatrice Diagnostics (Basel) Review Dermatofibroma (DF) or fibrous histiocytoma is one of the most frequent benign cutaneous soft-tissue lesions, characterized by a post-inflammatory tissue reaction associated with fibrosis of the dermis. Clinically DFs have a polymorphous clinical aspect from the solitary, firm, single nodules to multiple papules with a relatively smooth surface. However, multiple atypical clinicopathological variants of DFs have been reported and, therefore, clinical recognition may become challenging, leading to a more burdensome identification and sometimes to misdiagnosis. Dermoscopy is considered an important tool in DFs diagnosis, as it improves diagnostic accuracy for clinically amelanotic nodules. Although typical dermoscopic patterns are most frequently seen in clinical practice, there have also been some atypical variants described, mimicking some underlying recurrent and sometimes harmful skin afflictions. Usually, no treatment is required, although an appropriate work-up may be necessary in specific cases, such as in the presence of atypical variants or a history of recent changes. This narrative review’s aim is to summarize current evidence regarding clinical presentation, positive and differential diagnosis of atypical dermatofibromas and also to raise awareness about the importance of specific characteristics of atypical variants to better differentiate them from malignant conditions. MDPI 2023-02-10 /pmc/articles/PMC9955442/ /pubmed/36832159 http://dx.doi.org/10.3390/diagnostics13040671 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Orzan, Olguța Anca Dorobanțu, Alexandra Maria Gurău, Cristian Dorin Ali, Sibel Mihai, Mara Mădălina Popa, Liliana Gabriela Giurcăneanu, Călin Tudose, Irina Bălăceanu, Beatrice Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title | Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title_full | Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title_fullStr | Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title_full_unstemmed | Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title_short | Challenging Patterns of Atypical Dermatofibromas and Promising Diagnostic Tools for Differential Diagnosis of Malignant Lesions |
title_sort | challenging patterns of atypical dermatofibromas and promising diagnostic tools for differential diagnosis of malignant lesions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955442/ https://www.ncbi.nlm.nih.gov/pubmed/36832159 http://dx.doi.org/10.3390/diagnostics13040671 |
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