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Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma

Peptidyl arginine deiminases (PAD) enzymes have been investigated in various cancers. Recently, PAD enzyme, in particular PAD2, has been further implicated in cancers. Although the expression of PAD2 was significantly higher in hepatocellular carcinoma (HCC) tissue, its diagnostic or prognostic role...

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Autores principales: Uhm, Sunho, Cho, Yoon Ah, Choe, Ji-Young, Park, Ji Won, Kim, Min-Jeong, Han, Won-Ho, Lee, Junyong, Lee, Jung Woo, Shin, Dong Woo, Soh, Jae Seung, Lim, Hyun, Kang, Ho Suk, Moon, Sung-Hoon, Kim, Sung-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955443/
https://www.ncbi.nlm.nih.gov/pubmed/36832148
http://dx.doi.org/10.3390/diagnostics13040659
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author Uhm, Sunho
Cho, Yoon Ah
Choe, Ji-Young
Park, Ji Won
Kim, Min-Jeong
Han, Won-Ho
Lee, Junyong
Lee, Jung Woo
Shin, Dong Woo
Soh, Jae Seung
Lim, Hyun
Kang, Ho Suk
Moon, Sung-Hoon
Kim, Sung-Eun
author_facet Uhm, Sunho
Cho, Yoon Ah
Choe, Ji-Young
Park, Ji Won
Kim, Min-Jeong
Han, Won-Ho
Lee, Junyong
Lee, Jung Woo
Shin, Dong Woo
Soh, Jae Seung
Lim, Hyun
Kang, Ho Suk
Moon, Sung-Hoon
Kim, Sung-Eun
author_sort Uhm, Sunho
collection PubMed
description Peptidyl arginine deiminases (PAD) enzymes have been investigated in various cancers. Recently, PAD enzyme, in particular PAD2, has been further implicated in cancers. Although the expression of PAD2 was significantly higher in hepatocellular carcinoma (HCC) tissue, its diagnostic or prognostic role of PAD2 in HCC patients is unknown. This study investigated whether the expression of PAD2 affects recurrence and survival in HCC patients who underwent hepatic resection. One hundred and twenty-two HCC patients after hepatic resection were enrolled. The median follow-up was 41 months (range 1–213 months) in enrolled patients. To investigate an association between PAD2 expression level and the clinical characteristics of enrolled patients, the recurrence of HCC following surgical resection and survival of the patients were examined. Ninety-eight cases (80.3%) of HCC demonstrated a higher expression of PAD2. The expression of PAD2 was correlated with age, hepatitis B virus positivity, hypertension, and higher alpha-fetoprotein level. There was no association between PAD2 expression and sex, diabetes mellitus, Child–Pugh class, major portal vein invasion, HCC size or number. The recurrence rates in patients with lower PAD2 expression were higher than those with higher PAD2 expression. The cumulative survival rates of patients with higher PAD2 expression were better than those of patients with lower PAD2 expression, but it was not statistically significant. In conclusion, PAD2 expression is closely associated with recurrence of HCC patients following surgical resection.
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spelling pubmed-99554432023-02-25 Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma Uhm, Sunho Cho, Yoon Ah Choe, Ji-Young Park, Ji Won Kim, Min-Jeong Han, Won-Ho Lee, Junyong Lee, Jung Woo Shin, Dong Woo Soh, Jae Seung Lim, Hyun Kang, Ho Suk Moon, Sung-Hoon Kim, Sung-Eun Diagnostics (Basel) Article Peptidyl arginine deiminases (PAD) enzymes have been investigated in various cancers. Recently, PAD enzyme, in particular PAD2, has been further implicated in cancers. Although the expression of PAD2 was significantly higher in hepatocellular carcinoma (HCC) tissue, its diagnostic or prognostic role of PAD2 in HCC patients is unknown. This study investigated whether the expression of PAD2 affects recurrence and survival in HCC patients who underwent hepatic resection. One hundred and twenty-two HCC patients after hepatic resection were enrolled. The median follow-up was 41 months (range 1–213 months) in enrolled patients. To investigate an association between PAD2 expression level and the clinical characteristics of enrolled patients, the recurrence of HCC following surgical resection and survival of the patients were examined. Ninety-eight cases (80.3%) of HCC demonstrated a higher expression of PAD2. The expression of PAD2 was correlated with age, hepatitis B virus positivity, hypertension, and higher alpha-fetoprotein level. There was no association between PAD2 expression and sex, diabetes mellitus, Child–Pugh class, major portal vein invasion, HCC size or number. The recurrence rates in patients with lower PAD2 expression were higher than those with higher PAD2 expression. The cumulative survival rates of patients with higher PAD2 expression were better than those of patients with lower PAD2 expression, but it was not statistically significant. In conclusion, PAD2 expression is closely associated with recurrence of HCC patients following surgical resection. MDPI 2023-02-10 /pmc/articles/PMC9955443/ /pubmed/36832148 http://dx.doi.org/10.3390/diagnostics13040659 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uhm, Sunho
Cho, Yoon Ah
Choe, Ji-Young
Park, Ji Won
Kim, Min-Jeong
Han, Won-Ho
Lee, Junyong
Lee, Jung Woo
Shin, Dong Woo
Soh, Jae Seung
Lim, Hyun
Kang, Ho Suk
Moon, Sung-Hoon
Kim, Sung-Eun
Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title_full Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title_fullStr Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title_full_unstemmed Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title_short Expression of Peptidyl Arginine Deiminase 2 Is Closely Associated with Recurrence in Patients with Hepatocellular Carcinoma
title_sort expression of peptidyl arginine deiminase 2 is closely associated with recurrence in patients with hepatocellular carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955443/
https://www.ncbi.nlm.nih.gov/pubmed/36832148
http://dx.doi.org/10.3390/diagnostics13040659
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