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HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series
Purpose: One of the most known sexually transmitted diseases is Condylomata acuminata (CA), a skin lesion occurring due to infection from Human Papilloma Virus (HPV). CA has a typical appearance of raised, skin-colored papules ranging in size from 1 mm to 5 mm. These lesions often form cauliflower-l...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955444/ https://www.ncbi.nlm.nih.gov/pubmed/36832190 http://dx.doi.org/10.3390/diagnostics13040702 |
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author | Kosmidis, Christoforos Sevva, Christina Magra, Vasiliki Varsamis, Nikolaos Koulouris, Charilaos Charalampous, Ioannis Papadopoulos, Konstantinos Roulia, Panagiota Dagher, Marios Theodorou, Vasiliki Mystakidou, Chrysi Maria Kesisoglou, Isaak |
author_facet | Kosmidis, Christoforos Sevva, Christina Magra, Vasiliki Varsamis, Nikolaos Koulouris, Charilaos Charalampous, Ioannis Papadopoulos, Konstantinos Roulia, Panagiota Dagher, Marios Theodorou, Vasiliki Mystakidou, Chrysi Maria Kesisoglou, Isaak |
author_sort | Kosmidis, Christoforos |
collection | PubMed |
description | Purpose: One of the most known sexually transmitted diseases is Condylomata acuminata (CA), a skin lesion occurring due to infection from Human Papilloma Virus (HPV). CA has a typical appearance of raised, skin-colored papules ranging in size from 1 mm to 5 mm. These lesions often form cauliflower-like plaques. Depending on the involved HPV-subtype (either high-risk or low-risk) and its malignant potential, these lesions are likely to lead to malignant transformation when specific HPV subtypes and other risk factors are present. Therefore, high clinical suspicion is required when examining the anal and perianal area. Methods: In this article, the authors aim to present the results of a five-year case series (2016–2021) of anal and perianal cases of CA. Results: A total of 35 patients were included in this study. Patients were categorized based on specific criteria, which included gender, sex preferences, and human immunodeficiency virus infection. All patients underwent proctoscopy and excision biopsies were obtained. Based on dysplasia grade patients were further categorized. The group of patients where high-dysplasia squamous cell carcinoma was present was initially treated with chemoradiotherapy. Abdominoperineal resection was necessary in five cases after local recurrence. Conclusions: CA remains a serious condition where several treatment options are available if detected early. Delay in diagnosis can lead to malignant transformation, often leaving abdominoperineal resection as the only option. Vaccination against HPV poses a key role in eliminating the transmission of the virus, and thus the prevalence of CA. |
format | Online Article Text |
id | pubmed-9955444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99554442023-02-25 HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series Kosmidis, Christoforos Sevva, Christina Magra, Vasiliki Varsamis, Nikolaos Koulouris, Charilaos Charalampous, Ioannis Papadopoulos, Konstantinos Roulia, Panagiota Dagher, Marios Theodorou, Vasiliki Mystakidou, Chrysi Maria Kesisoglou, Isaak Diagnostics (Basel) Article Purpose: One of the most known sexually transmitted diseases is Condylomata acuminata (CA), a skin lesion occurring due to infection from Human Papilloma Virus (HPV). CA has a typical appearance of raised, skin-colored papules ranging in size from 1 mm to 5 mm. These lesions often form cauliflower-like plaques. Depending on the involved HPV-subtype (either high-risk or low-risk) and its malignant potential, these lesions are likely to lead to malignant transformation when specific HPV subtypes and other risk factors are present. Therefore, high clinical suspicion is required when examining the anal and perianal area. Methods: In this article, the authors aim to present the results of a five-year case series (2016–2021) of anal and perianal cases of CA. Results: A total of 35 patients were included in this study. Patients were categorized based on specific criteria, which included gender, sex preferences, and human immunodeficiency virus infection. All patients underwent proctoscopy and excision biopsies were obtained. Based on dysplasia grade patients were further categorized. The group of patients where high-dysplasia squamous cell carcinoma was present was initially treated with chemoradiotherapy. Abdominoperineal resection was necessary in five cases after local recurrence. Conclusions: CA remains a serious condition where several treatment options are available if detected early. Delay in diagnosis can lead to malignant transformation, often leaving abdominoperineal resection as the only option. Vaccination against HPV poses a key role in eliminating the transmission of the virus, and thus the prevalence of CA. MDPI 2023-02-13 /pmc/articles/PMC9955444/ /pubmed/36832190 http://dx.doi.org/10.3390/diagnostics13040702 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kosmidis, Christoforos Sevva, Christina Magra, Vasiliki Varsamis, Nikolaos Koulouris, Charilaos Charalampous, Ioannis Papadopoulos, Konstantinos Roulia, Panagiota Dagher, Marios Theodorou, Vasiliki Mystakidou, Chrysi Maria Kesisoglou, Isaak HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title | HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title_full | HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title_fullStr | HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title_full_unstemmed | HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title_short | HPV-Induced Anal and Peri-Anal Neoplasia, a Surgeon’s Experience: 5-Year Case Series |
title_sort | hpv-induced anal and peri-anal neoplasia, a surgeon’s experience: 5-year case series |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955444/ https://www.ncbi.nlm.nih.gov/pubmed/36832190 http://dx.doi.org/10.3390/diagnostics13040702 |
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