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An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
(1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955685/ https://www.ncbi.nlm.nih.gov/pubmed/36826131 http://dx.doi.org/10.3390/curroncol30020170 |
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author | Yanagisawa, Takafumi Rajwa, Pawel Kawada, Tatsushi Bekku, Kensuke Laukhtina, Ekaterina von Deimling, Markus Majdoub, Muhammad Chlosta, Marcin Karakiewicz, Pierre I. Heidenreich, Axel Kimura, Takahiro Shariat, Shahrokh F. |
author_facet | Yanagisawa, Takafumi Rajwa, Pawel Kawada, Tatsushi Bekku, Kensuke Laukhtina, Ekaterina von Deimling, Markus Majdoub, Muhammad Chlosta, Marcin Karakiewicz, Pierre I. Heidenreich, Axel Kimura, Takahiro Shariat, Shahrokh F. |
author_sort | Yanagisawa, Takafumi |
collection | PubMed |
description | (1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods: Three databases were queried in September 2022 for publications that analyzed mPCa patients treated with cytoreductive prostatectomy without restrictions. The outcomes of interest were progression-free survival (PFS), cancer-specific survival (CSS), overall survival (OS), perioperative complication rates, and functional outcomes following cRP. (3) Results: Overall, 26 studies were included in this systematic review. Among eight population-based studies, cRP was associated with a reduced risk of CSS and OS compared with no local therapy (NLT) after adjusting for the effects of possible confounders. Furthermore, one population-based study showed that cRP reduced the risk of CSS even when compared with radiotherapy (RT) of the prostate after adjusting for the effects of possible confounders. In addition, one randomized controlled trial (RCT) demonstrated that local therapy (comprising 85% of cRP) significantly improved the prostate-specific antigen (PSA)-PFS and OS. Overall, cRP had acceptable perioperative complication rates and functional outcomes. (4) Conclusions: Mounting evidence suggests that cRP offers promising oncological and functional outcomes and technical feasibility and that it is associated with limited complications. Well-designed RCTs that limit selection bias in patients treated with cRP are warranted. |
format | Online Article Text |
id | pubmed-9955685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99556852023-02-25 An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer Yanagisawa, Takafumi Rajwa, Pawel Kawada, Tatsushi Bekku, Kensuke Laukhtina, Ekaterina von Deimling, Markus Majdoub, Muhammad Chlosta, Marcin Karakiewicz, Pierre I. Heidenreich, Axel Kimura, Takahiro Shariat, Shahrokh F. Curr Oncol Review (1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods: Three databases were queried in September 2022 for publications that analyzed mPCa patients treated with cytoreductive prostatectomy without restrictions. The outcomes of interest were progression-free survival (PFS), cancer-specific survival (CSS), overall survival (OS), perioperative complication rates, and functional outcomes following cRP. (3) Results: Overall, 26 studies were included in this systematic review. Among eight population-based studies, cRP was associated with a reduced risk of CSS and OS compared with no local therapy (NLT) after adjusting for the effects of possible confounders. Furthermore, one population-based study showed that cRP reduced the risk of CSS even when compared with radiotherapy (RT) of the prostate after adjusting for the effects of possible confounders. In addition, one randomized controlled trial (RCT) demonstrated that local therapy (comprising 85% of cRP) significantly improved the prostate-specific antigen (PSA)-PFS and OS. Overall, cRP had acceptable perioperative complication rates and functional outcomes. (4) Conclusions: Mounting evidence suggests that cRP offers promising oncological and functional outcomes and technical feasibility and that it is associated with limited complications. Well-designed RCTs that limit selection bias in patients treated with cRP are warranted. MDPI 2023-02-10 /pmc/articles/PMC9955685/ /pubmed/36826131 http://dx.doi.org/10.3390/curroncol30020170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yanagisawa, Takafumi Rajwa, Pawel Kawada, Tatsushi Bekku, Kensuke Laukhtina, Ekaterina von Deimling, Markus Majdoub, Muhammad Chlosta, Marcin Karakiewicz, Pierre I. Heidenreich, Axel Kimura, Takahiro Shariat, Shahrokh F. An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title | An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title_full | An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title_fullStr | An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title_full_unstemmed | An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title_short | An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer |
title_sort | updated systematic and comprehensive review of cytoreductive prostatectomy for metastatic prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955685/ https://www.ncbi.nlm.nih.gov/pubmed/36826131 http://dx.doi.org/10.3390/curroncol30020170 |
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