Cargando…

An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer

(1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods...

Descripción completa

Detalles Bibliográficos
Autores principales: Yanagisawa, Takafumi, Rajwa, Pawel, Kawada, Tatsushi, Bekku, Kensuke, Laukhtina, Ekaterina, von Deimling, Markus, Majdoub, Muhammad, Chlosta, Marcin, Karakiewicz, Pierre I., Heidenreich, Axel, Kimura, Takahiro, Shariat, Shahrokh F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955685/
https://www.ncbi.nlm.nih.gov/pubmed/36826131
http://dx.doi.org/10.3390/curroncol30020170
_version_ 1784894407546241024
author Yanagisawa, Takafumi
Rajwa, Pawel
Kawada, Tatsushi
Bekku, Kensuke
Laukhtina, Ekaterina
von Deimling, Markus
Majdoub, Muhammad
Chlosta, Marcin
Karakiewicz, Pierre I.
Heidenreich, Axel
Kimura, Takahiro
Shariat, Shahrokh F.
author_facet Yanagisawa, Takafumi
Rajwa, Pawel
Kawada, Tatsushi
Bekku, Kensuke
Laukhtina, Ekaterina
von Deimling, Markus
Majdoub, Muhammad
Chlosta, Marcin
Karakiewicz, Pierre I.
Heidenreich, Axel
Kimura, Takahiro
Shariat, Shahrokh F.
author_sort Yanagisawa, Takafumi
collection PubMed
description (1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods: Three databases were queried in September 2022 for publications that analyzed mPCa patients treated with cytoreductive prostatectomy without restrictions. The outcomes of interest were progression-free survival (PFS), cancer-specific survival (CSS), overall survival (OS), perioperative complication rates, and functional outcomes following cRP. (3) Results: Overall, 26 studies were included in this systematic review. Among eight population-based studies, cRP was associated with a reduced risk of CSS and OS compared with no local therapy (NLT) after adjusting for the effects of possible confounders. Furthermore, one population-based study showed that cRP reduced the risk of CSS even when compared with radiotherapy (RT) of the prostate after adjusting for the effects of possible confounders. In addition, one randomized controlled trial (RCT) demonstrated that local therapy (comprising 85% of cRP) significantly improved the prostate-specific antigen (PSA)-PFS and OS. Overall, cRP had acceptable perioperative complication rates and functional outcomes. (4) Conclusions: Mounting evidence suggests that cRP offers promising oncological and functional outcomes and technical feasibility and that it is associated with limited complications. Well-designed RCTs that limit selection bias in patients treated with cRP are warranted.
format Online
Article
Text
id pubmed-9955685
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99556852023-02-25 An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer Yanagisawa, Takafumi Rajwa, Pawel Kawada, Tatsushi Bekku, Kensuke Laukhtina, Ekaterina von Deimling, Markus Majdoub, Muhammad Chlosta, Marcin Karakiewicz, Pierre I. Heidenreich, Axel Kimura, Takahiro Shariat, Shahrokh F. Curr Oncol Review (1) Background: Local therapy is highly promising in a multimodal approach strategy for patients with low-volume metastatic prostate cancer (mPCa). We aimed to systematically assess and summarize the safety, oncologic, and functional outcomes of cytoreductive prostatectomy (cRP) in mPCa. (2) Methods: Three databases were queried in September 2022 for publications that analyzed mPCa patients treated with cytoreductive prostatectomy without restrictions. The outcomes of interest were progression-free survival (PFS), cancer-specific survival (CSS), overall survival (OS), perioperative complication rates, and functional outcomes following cRP. (3) Results: Overall, 26 studies were included in this systematic review. Among eight population-based studies, cRP was associated with a reduced risk of CSS and OS compared with no local therapy (NLT) after adjusting for the effects of possible confounders. Furthermore, one population-based study showed that cRP reduced the risk of CSS even when compared with radiotherapy (RT) of the prostate after adjusting for the effects of possible confounders. In addition, one randomized controlled trial (RCT) demonstrated that local therapy (comprising 85% of cRP) significantly improved the prostate-specific antigen (PSA)-PFS and OS. Overall, cRP had acceptable perioperative complication rates and functional outcomes. (4) Conclusions: Mounting evidence suggests that cRP offers promising oncological and functional outcomes and technical feasibility and that it is associated with limited complications. Well-designed RCTs that limit selection bias in patients treated with cRP are warranted. MDPI 2023-02-10 /pmc/articles/PMC9955685/ /pubmed/36826131 http://dx.doi.org/10.3390/curroncol30020170 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yanagisawa, Takafumi
Rajwa, Pawel
Kawada, Tatsushi
Bekku, Kensuke
Laukhtina, Ekaterina
von Deimling, Markus
Majdoub, Muhammad
Chlosta, Marcin
Karakiewicz, Pierre I.
Heidenreich, Axel
Kimura, Takahiro
Shariat, Shahrokh F.
An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title_full An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title_fullStr An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title_full_unstemmed An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title_short An Updated Systematic and Comprehensive Review of Cytoreductive Prostatectomy for Metastatic Prostate Cancer
title_sort updated systematic and comprehensive review of cytoreductive prostatectomy for metastatic prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955685/
https://www.ncbi.nlm.nih.gov/pubmed/36826131
http://dx.doi.org/10.3390/curroncol30020170
work_keys_str_mv AT yanagisawatakafumi anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT rajwapawel anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT kawadatatsushi anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT bekkukensuke anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT laukhtinaekaterina anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT vondeimlingmarkus anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT majdoubmuhammad anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT chlostamarcin anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT karakiewiczpierrei anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT heidenreichaxel anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT kimuratakahiro anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT shariatshahrokhf anupdatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT yanagisawatakafumi updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT rajwapawel updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT kawadatatsushi updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT bekkukensuke updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT laukhtinaekaterina updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT vondeimlingmarkus updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT majdoubmuhammad updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT chlostamarcin updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT karakiewiczpierrei updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT heidenreichaxel updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT kimuratakahiro updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer
AT shariatshahrokhf updatedsystematicandcomprehensivereviewofcytoreductiveprostatectomyformetastaticprostatecancer