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Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience

Objective: The purpose of this study was to investigate the effectiveness of corticosteroid therapy for children suffering from Sydenham chorea (SC). Methods: The design of the study was observational, retrospective and conducted at the single center of the Rheumatology Unit of Policlinic Hospital o...

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Autores principales: Cappellari, Alberto Maria, Rogani, Greta, Filocamo, Giovanni, Petaccia, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955750/
https://www.ncbi.nlm.nih.gov/pubmed/36832391
http://dx.doi.org/10.3390/children10020262
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author Cappellari, Alberto Maria
Rogani, Greta
Filocamo, Giovanni
Petaccia, Antonella
author_facet Cappellari, Alberto Maria
Rogani, Greta
Filocamo, Giovanni
Petaccia, Antonella
author_sort Cappellari, Alberto Maria
collection PubMed
description Objective: The purpose of this study was to investigate the effectiveness of corticosteroid therapy for children suffering from Sydenham chorea (SC). Methods: The design of the study was observational, retrospective and conducted at the single center of the Rheumatology Unit of Policlinic Hospital of Milan, Italy, from May 1995 to May 2022. All data about the patients were collected from medical records. Results: From a total of 59 patients enrolled in the study (44 females and 15 males; median age 9.3 years, range 7.4–10.6 years), 49 were eligible for primary outcome analysis (10 patients were excluded due to incomplete data). Overall, 75% of patients received steroid therapy, while the remaining cases were treated with symptomatic drugs, including neuroleptics and antiseizure drugs. We found that the duration of chorea was significantly shorter in patients treated with corticosteroids in comparison to those receiving symptomatic treatment (median time: 31 vs. 41 days, p = 0.023). Additionally, patients with arthritis at the onset of the disease had a longer duration of chorea than those without arthritis (median time 90.5 vs. 39 days, p = 0.02). We also found that chorea recurred in 12% of the patients and seemed to be linked to a younger age at onset (p = 0.01). Conclusions: The study suggests that corticosteroid therapy can lead to a faster resolution of SC when compared to neuroleptics and antiseizure drugs treatment.
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spelling pubmed-99557502023-02-25 Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience Cappellari, Alberto Maria Rogani, Greta Filocamo, Giovanni Petaccia, Antonella Children (Basel) Brief Report Objective: The purpose of this study was to investigate the effectiveness of corticosteroid therapy for children suffering from Sydenham chorea (SC). Methods: The design of the study was observational, retrospective and conducted at the single center of the Rheumatology Unit of Policlinic Hospital of Milan, Italy, from May 1995 to May 2022. All data about the patients were collected from medical records. Results: From a total of 59 patients enrolled in the study (44 females and 15 males; median age 9.3 years, range 7.4–10.6 years), 49 were eligible for primary outcome analysis (10 patients were excluded due to incomplete data). Overall, 75% of patients received steroid therapy, while the remaining cases were treated with symptomatic drugs, including neuroleptics and antiseizure drugs. We found that the duration of chorea was significantly shorter in patients treated with corticosteroids in comparison to those receiving symptomatic treatment (median time: 31 vs. 41 days, p = 0.023). Additionally, patients with arthritis at the onset of the disease had a longer duration of chorea than those without arthritis (median time 90.5 vs. 39 days, p = 0.02). We also found that chorea recurred in 12% of the patients and seemed to be linked to a younger age at onset (p = 0.01). Conclusions: The study suggests that corticosteroid therapy can lead to a faster resolution of SC when compared to neuroleptics and antiseizure drugs treatment. MDPI 2023-01-31 /pmc/articles/PMC9955750/ /pubmed/36832391 http://dx.doi.org/10.3390/children10020262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Cappellari, Alberto Maria
Rogani, Greta
Filocamo, Giovanni
Petaccia, Antonella
Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title_full Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title_fullStr Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title_full_unstemmed Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title_short Corticosteroid Treatment in Sydenham Chorea: A 27-Year Tertiary Referral Center Experience
title_sort corticosteroid treatment in sydenham chorea: a 27-year tertiary referral center experience
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955750/
https://www.ncbi.nlm.nih.gov/pubmed/36832391
http://dx.doi.org/10.3390/children10020262
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