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Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction

Aims. We explored multiple cardiometabolic patterns, including inflammatory and congestive pathways, in patients with heart failure (HF). Methods and Results. We enrolled 270 HF patients with reduced (<50%, HFrEF; n = 96) and preserved (≥50%, HFpEF; n = 174) ejection fraction. In HFpEF, glycated...

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Autores principales: Balletti, Alessio, De Biase, Nicolò, Del Punta, Lavinia, Filidei, Francesco, Armenia, Silvia, Masi, Filippo, Di Fiore, Valerio, Mazzola, Matteo, Bacca, Alessandra, Dini, Frank L., Taddei, Stefano, Masi, Stefano, Pugliese, Nicola Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955832/
https://www.ncbi.nlm.nih.gov/pubmed/36832278
http://dx.doi.org/10.3390/diagnostics13040790
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author Balletti, Alessio
De Biase, Nicolò
Del Punta, Lavinia
Filidei, Francesco
Armenia, Silvia
Masi, Filippo
Di Fiore, Valerio
Mazzola, Matteo
Bacca, Alessandra
Dini, Frank L.
Taddei, Stefano
Masi, Stefano
Pugliese, Nicola Riccardo
author_facet Balletti, Alessio
De Biase, Nicolò
Del Punta, Lavinia
Filidei, Francesco
Armenia, Silvia
Masi, Filippo
Di Fiore, Valerio
Mazzola, Matteo
Bacca, Alessandra
Dini, Frank L.
Taddei, Stefano
Masi, Stefano
Pugliese, Nicola Riccardo
author_sort Balletti, Alessio
collection PubMed
description Aims. We explored multiple cardiometabolic patterns, including inflammatory and congestive pathways, in patients with heart failure (HF). Methods and Results. We enrolled 270 HF patients with reduced (<50%, HFrEF; n = 96) and preserved (≥50%, HFpEF; n = 174) ejection fraction. In HFpEF, glycated hemoglobin (Hb1Ac) seemed to be relevant in its relationship with inflammation as Hb1Ac positively correlated with high-sensitivity C-reactive protein (hs-CRP; Spearman’s rank correlation coefficient ρ = 0.180, p < 0.05). In HFrEF, we found a correlation between Hb1Ac and norepinephrine (ρ = 0.207, p < 0.05). In HFpEF, we found a positive correlation between Hb1Ac and congestion expressed as pulmonary B lines (ρ = 0.187, p < 0.05); the inverse correlation, although not significant, was found in HFrEF between Hb1Ac and N-terminal pro-B-type natriuretic peptide (ρ = 0.079) and between Hb1Ac and B lines (ρ = −0.051). In HFrEF, we found a positive correlation between E/e’ ratio and Hb1Ac (ρ = 0.203, p < 0.05) and a negative correlation between tricuspid annular systolic excursion (TAPSE)/echocardiographically measured systolic pulmonary artery pressure (sPAP) (TAPSE/sPAP ratio) (ρ = −0.205, p < 0.05) and Hb1Ac. In HFpEF, we found a negative correlation between TAPSE/sPAP ratio and uric acid (ρ = −0.216, p < 0.05). Conclusion. In HF patients, HFpEF and HFrEF phenotypes are characterized by different cardiometabolic indices related to distinct inflammatory and congestive pathways. Patients with HFpEF showed an important relationship between inflammatory and cardiometabolic parameters. Conversely, in HFrEF, there is a significant relationship between congestion and inflammation, while cardiometabolism appears not to influence inflammation, instead affecting sympathetic hyperactivation.
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spelling pubmed-99558322023-02-25 Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction Balletti, Alessio De Biase, Nicolò Del Punta, Lavinia Filidei, Francesco Armenia, Silvia Masi, Filippo Di Fiore, Valerio Mazzola, Matteo Bacca, Alessandra Dini, Frank L. Taddei, Stefano Masi, Stefano Pugliese, Nicola Riccardo Diagnostics (Basel) Article Aims. We explored multiple cardiometabolic patterns, including inflammatory and congestive pathways, in patients with heart failure (HF). Methods and Results. We enrolled 270 HF patients with reduced (<50%, HFrEF; n = 96) and preserved (≥50%, HFpEF; n = 174) ejection fraction. In HFpEF, glycated hemoglobin (Hb1Ac) seemed to be relevant in its relationship with inflammation as Hb1Ac positively correlated with high-sensitivity C-reactive protein (hs-CRP; Spearman’s rank correlation coefficient ρ = 0.180, p < 0.05). In HFrEF, we found a correlation between Hb1Ac and norepinephrine (ρ = 0.207, p < 0.05). In HFpEF, we found a positive correlation between Hb1Ac and congestion expressed as pulmonary B lines (ρ = 0.187, p < 0.05); the inverse correlation, although not significant, was found in HFrEF between Hb1Ac and N-terminal pro-B-type natriuretic peptide (ρ = 0.079) and between Hb1Ac and B lines (ρ = −0.051). In HFrEF, we found a positive correlation between E/e’ ratio and Hb1Ac (ρ = 0.203, p < 0.05) and a negative correlation between tricuspid annular systolic excursion (TAPSE)/echocardiographically measured systolic pulmonary artery pressure (sPAP) (TAPSE/sPAP ratio) (ρ = −0.205, p < 0.05) and Hb1Ac. In HFpEF, we found a negative correlation between TAPSE/sPAP ratio and uric acid (ρ = −0.216, p < 0.05). Conclusion. In HF patients, HFpEF and HFrEF phenotypes are characterized by different cardiometabolic indices related to distinct inflammatory and congestive pathways. Patients with HFpEF showed an important relationship between inflammatory and cardiometabolic parameters. Conversely, in HFrEF, there is a significant relationship between congestion and inflammation, while cardiometabolism appears not to influence inflammation, instead affecting sympathetic hyperactivation. MDPI 2023-02-20 /pmc/articles/PMC9955832/ /pubmed/36832278 http://dx.doi.org/10.3390/diagnostics13040790 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Balletti, Alessio
De Biase, Nicolò
Del Punta, Lavinia
Filidei, Francesco
Armenia, Silvia
Masi, Filippo
Di Fiore, Valerio
Mazzola, Matteo
Bacca, Alessandra
Dini, Frank L.
Taddei, Stefano
Masi, Stefano
Pugliese, Nicola Riccardo
Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title_full Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title_fullStr Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title_full_unstemmed Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title_short Cardiometabolic Phenotyping in Heart Failure: Differences between Patients with Reduced vs. Preserved Ejection Fraction
title_sort cardiometabolic phenotyping in heart failure: differences between patients with reduced vs. preserved ejection fraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955832/
https://www.ncbi.nlm.nih.gov/pubmed/36832278
http://dx.doi.org/10.3390/diagnostics13040790
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